Applications of PET and SPECT Molecular Imaging

Molecular imaging of mRNA can provide information on the expression pattern of genes at the cellular level and potentially determine early changes in disease [Pg.69]

It should be noted that radiolabeled glucose analogs for SPECT imaging have been investigated, but as of yet it is unclear if these agents wiU have widespread utility (33). [Pg.72]

Neuroimaging is one of the most widely studied areas for PET and SPECT. In particular, imaging of neurotransmitters and neuroreceptors in Parkinson s disease, schizophrenia, and cocaine addiction have been areas of particular interest (51). It is imperative that the radiolabeled substrates readily cross the [Pg.72]

Some of the more widely studied tumor receptors include somatostatin receptors, vasoactive intestinal peptide (VIP) receptors, gastrin-releasing [Pg.73]

MDR is a major issue for cancer chemotherapy that must be overcome for the successful use of many anti-cancer agents. One member of the adenosine triphosphate (ATP)-binding cassette (ABC) superfamily of membrane transporters that has been studied extensively for molecular imaging purposes has been the 170 kDa transmembrane glycoprotein, P-glycoprotein (Pgp). Two widely studied Tc-labeled agents that have been used for SPECT imaging of MDR [Pg.75]

Big Chemical Encyclopedia