Application of Microdialysis

K. Katayama, Y. Ohshima, M. Tomi, and K. Hosoya. Application of microdialysis to evaluate the efflux transport of estradiol 17-/7 glucuronide across the rat blood-retinal barrier. J. Neurosci. Methods 156 249-256 (2006). 

De Lange ECM, De Boer AG, Breimer DD (2000) Methodological issues in microdialysis sampling for pharmacokinetic studies. Adv Drug Deliv Rev 45 125-148 Elmquist WF, Sawchuk RJ (1997) Application of microdialysis in pharmacokinetic studies. Pharm Res 14 267-288 Evrard PA, Deridder G, Verbeeck RK (1996) Intravenous microdialysis in the mouse and the rat development and pharmacokinetic application of a new probe. Pharm Res 13 12-17 Jacobson I, Sandberg M, Hamberger A (1985) Mass transfer in brain dialysis devices a new method for the estimation of extracellular amino acids concentration. J Neurosci Methods 15 263-268... 

Microdialysis is, however, only a sampling technique. This means it provides an investigator with samples that must be chemically analyzed. In fact, the applicability of microdialysis to the study of a particular compound occurring in the extracellular fluid is entirely dependent on the sensitivity of the respective analytical technique. In this context, high performance liquid chromatography (HPLC) plays a key role in terms of sensitivity, reliability, and speed of... 

A particular application of microdialysis can be found in the so-called dialysis electrode . This device was first reported by Albery et al. [164] who constructed an electrochemical cell inside a concentric microdialysis probe, inserting three wire electrodes into the probe (Fig. 12.9). 

Recent trends in the application of microdialysis in bioprocess monitoring, such as innovative techniques for in vitro sampling, have been extensively reviewed by Torto et al. [20,186]. Thus, in the following section only a few examples of on-line couphng of microdialysis with biosensors will be focused... 

Applications of Microdialysis/Mass Spectrometry to Drug Discovery... 

The remainder of the chapter discusses microdialysis coupled to mass spectrometric detection to both on-line and off-line methods, with an emphasis on analysis of drugs. Applications of microdialysis/mass spectrometry to gas chro-matography (GC), liquid chromatography (LC), and flow injection into the mass spectrometer are discussed. In particular, approaches to overcome problems with introduction of high-ionic-strength dialysate into the mass spectrometer are described. 

Weiss, D. J., et al.. Applications of microdialysis/mass spectrometry to drug discovery, in The Mass Spectrometer in Drug Discovery A Practical Guide to Instrumentation, Experimental Strategies and Applications, Rossi, D. T. and Sinz, M. W. eds.. Chapter 12, Marcel Dekker, New York, 2001, pp. 377-397. 

Hocht, C., et al., Application of microdialysis for pharmacokinetic-pharmacodynamic modelling,... 

CLINICAL APPLICATIONS OF MICRODIALYSIS SAMPLING AND LIQUID CHROMATOGRAPHIC-BASED ANALYSIS... 

Muller M, Schmid R, Georgopoulos A, Buxbaum A, Wasicek C, Eichler HG. Application of microdialysis to clinical pharmacokinetics in humans. Clin Pharmacol Ther 1995 57 371-80. 

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