Anxiety cognitive function

Palomba et al. (2004) have also studied the effects on cognigtion, mood, and QoL in 100 premenopausal women with symptomatic uterine leiomyomas treated with gonadotropin-releasing hormone agonist with or without raloxifene. The findings demonstrate that raloxifene is not able to prevent decreases in cognitive function and does not reduce the depresion and anxiety symptoms in women treated with GnRHa. 

Dementia may be hard to differ from delirium (Table 6.1). The most important tool is a thorough medical history. Dementia has a slow progress whereas delirium is characterised by a rapid change in cognitive functions. Depression and anxiety could be mistaken for delirium, but the impaired consciousness in delirium sets it apart from affective disorders. 

To understand whether cognitive function and mood disorders are cooperatively influenced by genetic factors in AD and to know the potential impact that conventional neuroprotection can exert on mood disorders, we studied the effect of the therapeutic CNLA protocol on anxiety in AD and the differential APOE- and ACE-related responses distinguishing the influence of monogenic and bigenic variants on emotional conditions. 

Brown RG, Marsden CD Cognitive function in Parkinson s disease from description to theory. Trends Neurosci 13 21-29, 1990 Brown RG, Marsden CD Dual task performance and processing resources in normal subjects and patients with Parkinson s disease. Brain 114 215-231, 1991 Brown RP, Frances A, Kocsis JH, et al Psychotic vs. nonpsychotic depression comparison of treatment response. J Nerv Ment Dis 170 635-637, 1982 Brown SA, Irwin M, Schuckit MA Changes in anxiety among abstinent male alcoholics. J Stud Alcohol 52 55-61, 1991... 

This chapter deals with the question of how psychotropic drugs act upon cognitive functions in man. Some of the pertinent information, i.e. how single doses of these pharmaceuticals affect cognitive performance in healthy volunteers under experimental conditions, has been reviewed and discussed in Chapter 3. However, when dealing with drug effects in patients suffering from schizophrenia, depression, anxiety disorders, etc. one must expect a much... 

Benzodiazepines, barbiturates, and most older sedative-hypnotic drugs exert calming effects with concomitant reduction of anxiety at relatively low doses. In most cases, however, the anxiolytic actions of sedative-hypnotics are accompanied by some depressant effects on psychomotor and cognitive functions. In experimental animal models, benzodiazepines and older sedative-hypnotic drugs are able to disinhibit punishment-suppressed behavior. This disinhibition has been equated with antianxiety effects of sedative-hypnotics, and it is not a characteristic of all drugs that have sedative effects, eg, the... 

The NE system mediates various autonomic, neuroendocrine, emotional and cognitive functions. One of the central roles of NE is response to stress and aversion. This role can be summarized as an activation of response to the acute stress and aversion, followed by decreased reaction to repeated or chronic aversion. Since the response to stress and aversion is a basic part in pathology of mood disorder, NE should play an important role in anxiety, depression and mania. Indeed, this role has been demonstrated in numerous animal and human studies. Majority of antidepressant drugs and mood stabilizers affect NE system as their direct or indirect target. Various medications have different effects on NE neuronal activity. The majority of antidepressants, Li and benzodiazepines suppress NE transmission. Other medications, such as AADs, activate NE neuronal firing activity and NE release. Appropriate combination of different medications, based on the consideration of their effect on NE system, might be critical to obtain good treatment outcome. The combination of SSRIs... 

The 5-HT3 receptors are found in both the peripheral nervous system and central nervous system (CNS), where they mediate last synaptic transmission at synapses (3). In the CNS, they are located predominantly at intemeurones, where they modulate the release of a range of neurotransmitters (4-9). There is some evidence that 5-HT3 receptors play roles in brain reward mechanisms and in neurological phenomena such as anxiety, psychosis, nociception, and cognitive function (10,11), and in the first few years following the discovery of these receptors, there was also much interest in the therapeutic potential of 5-HT3 receptor antagonists for antipsychotic, antinociceptive, and other psychiatric disorders (12-15). This potential has not yet been realized, but there is still active research in this area (16), and their current major therapeutic target is against emesis in cancer chemotherapy and irritable bowel syndrome (17,18). 

These measures often focus on the frequency and intensity of psychological distress (e.g., anxiety or depression), and include the individual s perception of psychological well-being and life satisfaction and an assessment of cognitive functioning.Measures of this domain also cover the broad range of differences possible in the mental health continuum. Health disturbances commonly manifest themselves on behavioral and physical levels ... 

In addition to the deficiency of the cholinergic neurotransmission observed in AD and correlated with cognitive function disorders, AD patients also suffer from depression and anxiety. Serotonin transporters (SERT) inhibitors... 

---