Antithyroglobulin antibodies

Abbreviated New Drug Application antithyroglobulin antibody antithyroid peroxidase antibody area under the (time-concentration) curve beta-human chorionic gonadotropin central nervous system... 

A rise in the TSH level is the first evidence of primary hypothyroidism. Many patients have a free T4 level within the normal range (compensated hypothyroidism) and few, if any, symptoms of hypothyroidism. As the disease progresses, the free T4 concentration drops below the normal level. The T3 concentration is often maintained in the normal range despite a low T4. Antithyroid peroxidase antibodies and antithyroglobulin antibodies are likely to be elevated. The RAIU is not a useful test in the evaluation of hypothyroidism because it can be low, normal, or even elevated. 

In most patients with hyperthyroidism, T3, T4, RT3U, FT4, and FT4I will all be elevated and TSH is suppressed (Table 38-2). Radioiodine uptake is usually markedly elevated as well. Antithyroglobulin antibodies, thyroid peroxidase, and TSH-R Ab [stim] are often present. 

Antithyroglobulin antibodies can also be used to monitor residual disease and/or recurrence. Serial anti-Tg measurements may be an independent prognostic indicator of therapy, because an increase in anti-Tg antibodies may suggest recurrence of the tumor. ... 

IMA and RIA are the two main methods used for the measurement of Tg. The IMA assays have the advantage of having a shorter incubation time and are automatable however, they suffer from greater interferences. The main interferants in both assays are antithyroglobulin antibodies, which cause an underestimation of Tg levels in the IMA. Antithyroglobulin antibodies can either be measured directly in all patients or if both IMA and RIA are used to measure Tg, a discordant result suggests the presence of anti-thyroglobulin antibodies. 

Antithyroglobulin Antibody IRMA Test (package insert). Dana Point, CA BCronus Inc, 1987. 

Antithyroid perioxidase antibodies and antithyroglobulin antibodies are likely to be elevated. 

Nevirapine Polyclonal IgE Autoantibodies (type IV collagen, antinuclear antibodies antiacetylcholine, antithyroglobulin antibodies)... 

Adrenal angiography Adrenal venography Adrenocorticotropic hormone stimulation test Aldosterone assay, blood Androstenedione Antidiuretic hormone Antithyroglobulin antibody Antithyroid microsomal antibody Blood glucose Calcitonin Calcium Catecholamines Chromosome karyotype Computed tomography of adrenals Cortisol blood urine C-peptide... 

Antinuclear antibody test Antiscleroderma antibody Anti-smooth muscle antibody Antispermatozoal antibody Anti-SS-A and anti-SS-B antibody Antistreptolysin O titer Antithrombin III Antithyroglobulin antibody Antithyroid microsomal antibody Apolipoproteins Aspartate aminotransferase Atrial natriuretic factor Basophils Bilirubin Bleeding time... 

Figure 86.9 Changes in the distribution of antithyroglobulin antibodies for men (A/ = 494) and women N = 856).

TgAb Antithyroglobulin antibody TPOAb Antiperoxidase antibody TSBAb TSH receptor inhibiting antibodies TSH Thyrotropin... 

Even though TPOAb and antithyroglobulin antibody (TgAb) cross the placenta and are detected in blood from the umbilical cord, these would not exert cytotoxic action on the fetal thyroid. 

Finally, the role of antithyroglobulin antibodies in the etiology of endemic goiter has been suspected in Argentina (42) but has never been conclusively confirmed, either in endemic goiter and cretinism (43) or in sporadic congenital hypothyroidism (44). 

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