Antiradiant

A series of selenazolidines substituted in the 2-piosition have been synthesized to be used as antiradiation agents, but no results are yet available (94). 

Diphenylamine has shown activity against the body louse, chiggers, housefly, and, as the chloro derivative, against the red spider mite. Diarylamines have also been reported to have antiradiation activity (48). 

Antiradiation. An agent capable of counteracting the effects of radiation effective against radiation injury. 

Thiazetidines are investigated with special emphasis on their possible antiradiation drug activity. Certain 1,3-thiazetidines exhibit pesticidal activity. Compounds 21 are specifically eflective as insecticidal and acaricidal agents. 

A similar distribution has been discovered by Ringsdorf and his co-workers (67) for polymeric antiradiation substances after the first days of application, also with the help of audioradiography. After 14 and more days, however, a strong cumulation is found in the bone-tissue, most likely reducible to the chemical properties of these sulfur containing polymers. 

Such sulfinate compounds are water soluble and may be used as antiradiation drugs (see Section 7.4). Bis(sulfinato)trisulfanes may be converted to the corresponding bisalkyl esters by reaction with either diazomethane or a solution of BF3 in diethyl ether. When sodium polysulfide is apphed in equation (59) the resulting poly-sulfanes (equation 60) contain up to six sulfur atoms. However, bis(sulfinato)polysulfanes with more than four catenated sulfur atoms are unstable in water, and elemental sulfur is slowly precipitated. When the thiosulfonate RS(0)-(CH2)2-SS02C6H4Me was used in equations (59) and (60), the bis(sulfoxido)trisulfane [RS(0)-(CH2)2]2S3 resulted. ... 

The higher radiation protectiveness of polymeric compounds over low molecular weight compounds could be utilized in the design of radioprotective agents. A report dealing with the various polymeric antiradiation aibstances has been published ... 

Piper J.R., Stringfellow C.R., Elliot R.D., Johnston T.R, S-2-(omega-aminoalkylamino)ethyl dihydrogen phosphorothioates and related compounds as potential antiradiation agents, J. Med. Chem., 1969,12,236-243. 

Chapter 32. Antiradiation Agents William 0. Foye, Massachusetts College of Pharmacy, Boston... 

No correlation was found between the nature of X, antiradiation potency, or resistance of the disulfides to disproportionation by either thermal or photochemical meajis. Where X was located para, no protective activity was shown °... 

Due to the free-radical character of both the y-radiation induced transformation and oxidation in the post-irradiation phase, free-radical scavenging stabilizers - phenols and amines - effectively protect PO [11,226,227]. This was confirmed by excellent antioxidant/antiradiant effects of DP A, PNA and PD in particular in the post-y-irradiation phase of PO and elastomers [11]. Oligomeric DHQ 21 or its combination with 9b efficiently stabilized EPDM or X-LPE used as insulation materials for electric cables exposed to irradiation doses up to 2MGy at a dose rate 300 Gy h 1 [242]. 

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