Radioprotective agent

A number of phosphorothioates show anti-radiation activity and are excellent radioprotective agents. Some of these compounds are (12.127) [14]. 

The outcome of rapid radiation chemical processes in mammalian cells is to cause a variety of longer-Hved physical alterations in the DNA. Of these, double-strand breaks (DSBs) appear to be most frequently involved in cell killing if not correctly repaired. In general, thiols protect against DSB induction in proportion to their effect on cell killing (7), although there are exceptions (8). 

Modulation of the Killing of Mammalian Cells by Thiols. Important aspects of the effects of exogenous thiols on clonogenic cell survival following exposure to low linear energy transfer (LET) radiations include the following. 

Kirk-Othmer Encyclopedia of Chemical Technology (4th Edition) 

Our bodies are subject to continuous attack by ionizing radiation from cosmic rays from outer space, from y-rays from the natural radionuclides in the upper layers of the Earth s crust, and a, P, and y-rays from the radionuclides, C, etc., that are naturally present in our 

One compound, copper(n)di-isopropylsalicylate (Cu-DIPS), has been shown in mice to be very effective in reducing the severity of radiation damage when it is injected up to a few hours after irradiation, 

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