Antipsychotic agents cardiovascular effects

Antipsychotic agents may have several cardiovascular effects. Medication-induced hypotension is generally more problematic with lower-potency neuroleptics than with other antipsychotics and appears to be mediated through tti-adrenergic blockade. Besides increases in heart rate that may be the result of hypotension, antipsychotics with appreciable anticholinergic effects (see Clinical Implications, below) can lead to tachycardia (Gutgesell et ah, 1999). 

Microencapsulated solid preparations are widely used in pharmaceutical, chemical, and other industries to protect various substances from environmental impact, as well as for extending their action [137], In the pharmaceutical field, in particular, these preparations are mainly used to get controlled release drug kinetics, to minimize side effects, to reduce gastric irritations, and to mask the unpleasant taste of the contained drug [137-142]. Indeed, many different active components are microencapsulated analgesics, antibiotics, antihistamine, cardiovascular agents, iron salts, antipsychot-ics [143], vitamins, peptides [144], proteins [145], antiasthma [140,146], broncodilators, diuretics, anticancerogens, tranquilizers, and antihypertensives [137],... 

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