Antioxidants doxorubicin

Oxidative stress reduces the rate of cell proliferation, and that occurring during chemotherapy may interfere with the cytotoxic effects of antineoplastic drugs, which depend on rapid proliferation of cancer cells for optimal activity. Antioxidants detoxify ROS and may enhance the anticancer effects of chemotherapy. For some supplements, activities beyond their antioxidant properties, such as inhibition of topoisomerase II or protein tyrosine kinases, may also contribute. ROS cause or contribute to certain side effects that are common to many anticancer drugs, such as gastrointestinal toxicity and muagenesis. ROS also contribute to side effects that occur only with individual agents, such as doxorubicin-induced cardiotoxicity, cisplatin-induced nephrotoxicity, and bleomycin-induced pulmonary fibrosis. Antioxidants can reduce or prevent many of these side effects, and for some supplements the protective effect results from activities other than their antioxidant properties. Certain side effects, however, such as alopecia and myelosuppression, are not prevented... 

Uric acid in very low concentrations, very strongly absorbs UV radiation and for this reason, has been used to protect various FD C colors against fading when they will be probably exposed to direct sunlight (112). Uric acid has been found to enhance the photostability of solutions of colchicine (70) and FD C Blue No. 2 (82,113). Sodium urate, the neutral salt of uric acid, has a photoprotective effect on solutions of metronidazole (68), doxorubicin hydrochloride (77), and physostigmine sulfate (108). In addition to its photon-absorbing property, uric acid has been reported to also possess antioxidant quality (114). 

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