Antinociceptive activity carrageenan

Five lignans isolated from the heartwood of T. baccata L. growing in Turkey were evaluated for their anti-inflammatory and antinociceptive activities in vivo. All of the compounds were shown to possess significant antinociceptive activities against p-bcnzoquinone-induccd abdominal contractions and significantly inhibited carrageenan-induced hind paw edema in mice [100]. 

It has been consistently and repeatedly reported that the inflammatory process is accompanied by a seemingly paradoxical enhancement of the antinociceptive activity of opioids [152], For example, carrageenan-induced inflammation elicited a 30-fold increase in the ability of morphine to inhibit evoked activity of C-fibers [153]. The antinociceptive effect of morphine was similarly enhanced in arthritic rats [154], Further, the effect of ITH DAMGO... 

In addition to its effects on cell growth, CLP elicits antinociceptive and anti-inflammatory activities. Peripheral antinociceptive activity was investigated by acetic acid-induced writhing model. CLP (0.1-100 mcM/kg) inhibited acetic acid-induced abdominal constrictions dose dependently (1C50 = 0.0945). Central antinociceptive activity of CLP was demonstrated in the hot plate test. CLP (100 mcM/kg, p.o.) increased latency time 90, 120, and 150 min after treatment. Similarly, CLP caused an inhibition of nociception in formalin test. Anti-inflammatory activity of CLP was evaluated in capsaicin-induced ear edema and carrageenan-induced peripheral inflammation tests. Following oral administration at a dose of 100 mcM/kg, CLP inhibited capsaicin-induced ear edema by 55.8% and reduced leukocyte migration to the inflammatory sites by 48.3% [61]. 

In another study of the effects of A -THC on yeast-induced pyrexis, carrageenan-induced edema and yeast-induced rat paw hyperesthesia, the following results were obtained (l) The oral antipyretic potency of A -THC is approximately 2 times that of phenylbutazone, (2) A -THC was essentially devoid of antinociceptive activity except at elevated doses which produced a marked catatonic-like state, and (3) A -THC at doses up to and including 100 mg/kg was totally ineffective in reducing or preventing the edematous response. 

FQ on the rat formalin test. Neurosci Lett 262 179-182 Yamamoto T, Tatsuno I (1995) Antinociceptive effect of intrathecaUy administered pituitaiy adenylate cyclase activating peptide (PACAP) on the rat formalin test. Neurosci Lett 184 32—35 Yamamoto T, Wada T, Miyazaki R (2008) Analgesic effects of intrathecaUy administered 26RFa, an intrinsic agonist for GPR103, on formalin test and carrageenan test in rats. Neuroscience 157 214-222... 

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