Antihistaminic index

In the early days, when the role of histamine in allergy had been accepted, much discussion took place on the question of whether or not histamine reacts on an own receptor. In fact, this question was important, because it underlined whether or not it made sense to search for antihistamines. At the time, specific pharmacological models were not available, but one pioneer in the field was Staub, who defined an antihistaminic index (AHI). This was the number of LD5() doses blocked by 5 mg of the compound under investigation. In a model (which for ethical reasons would be completely unacceptable today), the test compound was dosed at 5 mg to mice (i.v.) and subsequently histamine was injected at one, two, three, etc., times the i.v. LD50 dose [5] ultimately, the parameter measured was lethality. 

Technique 29, Section 29.11). You may need to search a computerized database to get the necessary information, or you may be able to find it in the Aldrich Catalog Handbook of Fine Chemicals, issued by the Aldrich Chemical Company. Current issues of this catalogue include listings of substances by CAS number. In your report, you should also report the relative percentage of the substance in the tablet extract. Finally, your instructor may also ask you to include the "quality" parameter from the "hit list." If possible, determine which components have antihistamine activity and which ones are present for another purpose. The Merck Index may provide this information. 

Uses Synthetic fibers evaporation retardant on water surfaces surfactant for polymerization emollient in cosmetics foam control agent cosolvent plasticizer viscosity index improver mfg. of household/industrial cleaners, personal care prods., textile auxs., plasticizers, ore flotation, oil well drilling, metal lubricants, agric. additives raw material, consistency agent, emollient for pharmaceuticals as antihistamine in surf, lubricants for mfg. of food-contact metallic articles Regulatory FDA 21CFR 178.3910 Canada DSL... 

---