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Antigout drugs

Aspirin, salicylates, and thiazide diuretics should not be used with allopurinol. The dose of mercaptopurine should be reduced one-third or one-fourth when used with allopurinol. Acute poisoning of colchicine should be treated with gastric lavage and activated charcoal administration. Supportive maintenance measures for blood pressure and respiration should be provided. Probenecid is used by athletes to inhibit the urinary excretion of banned anabolic steroids.85 [Pg.344]

ANTIHYPERTENSIVES AND HEART FAILURE DRUGS Secondary drug ANTIGOUT DRUGS Effect Mechanism Precautions... [Pg.42]

BETA-BLOCKERS ANTIGOUT DRUGS-SULFINPYRAZONE Antihypertensive effects of oxprenolol 1 by sulfinpyrazone Unknown Monitor PR and BP closely consider starting an alternative beta-blocker... [Pg.69]

CALCIUM CHANNEL BLOCKERS ANTIGOUT DRUGS Serum concentrations pf verapamil are significantly 1 when co-administered with sulfinpyrazone Uncertain, but presumed to be due to t hepatic metabolism Monitor PR and BP at least weekly until stable. Watch for poor response to verapamil... [Pg.88]

THIAZIDES ANTIGOUT DRUGS Possible t risk of severe allergic reactions when allopurinol is given with thiazides in the presence of renal impairment Uncertain Caution in co-administering allopurinol with thiazides in the presence of renal insufficiency... [Pg.117]

CARBAMAZEPINE ANTIGOUT DRUGS -ALLOPURINOL High-dose allopurinol (600mg/day) may t carbamazepine levels over a period of several weeks. 300 mg/ day allopurinol does not seem to have this effect Uncertain Monitor carbamazepine levels in patients taking long-term, high-dose allopurinol... [Pg.217]

PHENYTOIN ANTIGOUT DRUGS- ALLOPURINOL, SULFINPYRAZONE Phenytoin levels may be t in some patients Uncertain Monitor phenytoin levels... [Pg.223]

CYCLOPHOSPHAMIDE ANTIGOUT DRUGS-ALLOPURINOL t risk of bone marrow suppression Uncertain but allopurinol seems to T cyclophosphamide levels Monitor FBC closely... [Pg.295]

CAPECITABINE ANTIGOUT DRUGS-ALLOPURINOL Possible 1 efficacy of capecitabine Capecitabine is a prodrug for fluorouracil it is uncertain at which point allopurinol acts on the metabolic pathway Manufacturers recommend avoiding co-administration... [Pg.306]

MERCAPTOPURINE ANTIGOUT DRUGS -ALLOPURINOL t mercaptopurine levels with risk of toxicity (e.g. myelosuppression, pancreatitis) Azathioprine is metabolized to mercaptopurine. Allopurinol inhibits hepatic metabolism of mercaptopurine 1 doses of azathioprine and mercaptopurine by up to three-quarters and monitor FBC, LFTs and amylase carefully... [Pg.317]

METHOTREXATE ANTIGOUT DRUGS -PROBENECID t methotrexate levels Probenecid 1 elimination of methotrexate renally by interfering with tubular secretion in the proximal tubule and also 1 protein binding of methotrexate (a relatively minor effect). Probenecid competes with methotrexate for renal elimination Avoid co-administration if possible if not possible, 1 dose of methotrexate and monitor FBC closely... [Pg.323]

PEMETREXED ANTIGOUT DRUGS -PROBENECID t pemetrexed levels Probable 1 renal excretion of pemetrexed Avoid co-administration where possible. If both need to be given, monitor FBC and renal function closely and watch for gastrointestinal disturbance and features of myopathy... [Pg.328]

AMINOSALICYLATES ANTIGOUT DRUGS -PROBENECID Aminosalicylate levels t by probenecid Probenecid competes with aminosalicylate for active renal excretion Watch for early features of toxicity of aminosalicylate. Consider 1 dose of aminosalicylate... [Pg.351]

NS AIDs ANTIGOUT DRUGS-PROBENECID T levels of indometacin, ketorolac and possibly dexketoprolien, ketoprofen, naproxen, tenoxicam and tiaprofenic acid Probenecid competitively inhibits renal metabolism of these NSAIDs Watch for signs of toxicity of these NSAIDs. Consider using an alternative NSAID. The manufacturers of ketorolac advise avoiding co-adminis-tration of ketorolac and probenecid... [Pg.466]

ALLOPURINOL PYRAZINAMIDE i efficacy of antigout drugs Pyrazinamide can induce hyperuricaemia Pyrazinamide should not be used in patients with gout... [Pg.482]

CEPHALOSPORINS ANTIGOUT DRUGS - PROBENECID t cephalosporin levels Uncertain Watch for t incidence of side-effects... [Pg.514]

MEROPENEM ANTIGOUT DRUGS - PROBENECID t meropenem levels Uncertain Manufacturers recommend avoiding co-administration... [Pg.514]

ERYTHROMYCIN, CLARITHROMYCIN ANTIGOUT DRUGS-COLCHICINE Cases of colchicine toxicity when macrolides added Uncertain macrolides may inhibit hepatic metabolism of colchicine. Clarithromycin and erythromycin both inhibit intestinal P-gp, which may T bioavailability of colchicine Monitor FBC and renal function closely... [Pg.520]

CIPROFLOXACIN, LEVOFLOXACIN, NALIDIXIC ACID, NORFLOXACIN ANTIGOUT DRUGS -PROBENECID t ciprofloxacin, nalidixic acid and norfloxacin levels Uncertain Watch for T incidence of side-effects. Moxifloxacin, ofloxacin and spar-floxacin do not seem to interact and could be used as alternative therapy... [Pg.529]

NITROFURANTOIN ANTIGOUT DRUGS- PROBENECID, SULFINPYRAZONE i efficacy of nitrofurantoin in urinaiy tract infections L urinary excretion Watch for poor response to nitrofurantoin... [Pg.557]

See other pages where Antigout drugs is mentioned: [Pg.449]    [Pg.593]    [Pg.593]    [Pg.344]    [Pg.55]    [Pg.362]    [Pg.395]    [Pg.417]    [Pg.427]    [Pg.441]    [Pg.481]    [Pg.482]    [Pg.482]    [Pg.483]    [Pg.483]    [Pg.484]    [Pg.484]    [Pg.485]    [Pg.485]    [Pg.486]    [Pg.486]    [Pg.487]    [Pg.487]    [Pg.525]   


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