Antigens biochemical sensors

Sensitive, selective detection of biochemically active compounds can be achieved by employing antigen-antibody, enzyme-substrate, and other receptor-protein pairs, several of which have been utilized in the development of piezoelectric immunoassay devices. The potential analytical uses of these materials has been reviewed, particularly with respect to the development of biochemical sensors [221-224], The receptor protein (e.g., enzyme, antibody) can be immobilized directly on the sensor surface, or it can be suspended in a suitable film or membrane. An example of the sensitivity and response range that can be... 

Utilize a biochemical mechanism for recognition. They are responsible for binding the analyte of interest to the sensor surface for the measurement. Bioreceptors can generally be classified into five major categories enzyme, antibody/antigen, nucleic acid/DNA, cellular structure/ceU, and biomimetic. The sampling component of a biosensor contains a biosensitive layer that can contain bioreceptors or be made of bioreceptors cova-lendy attached to the transducer. The most common forms of bioreceptors used in biosensing are based on ... 

With the exception of the Corning-476200 acetylcholine bromide-selective liquid membrane electrode, there are no commercially available bio-sensors which use ion-selective electrodes to indicate biochemically important compounds (such as proteins, antigens, hormones, enzymes and their substrates). Nonetheless, there is a large number of such devices which can be easily self-made, so that it is appropriate to briefly discuss them here. For further details the reader is referred to the excellent review articles by Rechnitz [173] and Moody and Thomas [174]. 

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