Antigen Metabolism

Interfaces play a predominant role in metabolic processes [78], as well as in immune recognition (e.g. T lymphocytes recognizing antigens on the surface of antigen presenting cells, section c2.14.6.2. Historically, the bulk of experimental... 

Urban, J.F. Jr and Douvres, F.W. (1981) In vitro development of Ascaris suum from third- to fourth-stage larvae and detection of metabolic antigens in multi-well culture systems. Journal of Parasitology 67, 800-806. 

Immunocytochemical staining with antibody-gold probes is a powerful way to detect, localize, and quantify antigen molecules in tissue sections and cells (Figure 24.3). Metabolic processes can be followed, epitope mapping of the structural characteristics of macromolecules can be... 

It is reasonable to presume that the immunogenic and adjuvant activity of lipospheres may be the result of a combination of factors. These factors may include a focused and enhanced delivery of the antigen to an antigen-presenting cell (macrophage) and protection of the antigen from metabolic destruction at other sites in the body that do no participate in the immune response. 

Naisbitt, D.J., Fraser Gordon, S., Pirmohamed, M., Burkhart, C., Cribb, A.E., Pichler, W.J., and Kevin Park, B., Antigenicity and immunogenicity of sulphamethoxazole demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo, Br. J. Pharmacol., 133, 295, 2001. 

McCloskey, T.W., Todaro, J.A., and Laskin, D.L., Lipopolysaccharide treatment of rats alters antigen expression and oxidative metabolism in hepatic macrophages and endothelial cells, Hepatology, 16, 191, 1992. 

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