Antifungal activity evaluation

In vitro antifungal activities evaluation for sampangine metabolites demonstrated comparable activities to sampangine. However, an in vivo efficacy study revealed that SAh 2 is inactive. The antifungal activity profile of sampangine metabolites led us to conclude that metabolism per se is not the cause for the in vivo inactivity of sampangine, hence, further studies on the other pharmacokinetic parameters (bioavailability, distribution, clearance, etc.) will be necessary. 

The yeasts also have been evaluated for antifungal activity. Spadaro and others (2008) reported that Hanseniaspora uvarum, Rhodotorula spp., and Metschnikowia pulcherrima reduced the development of P. expansum on apples. In this work the biocontrol effectiveness was assessed on four apple cultivars, Golden Delicious, Stark Delicious, Granny Smith, and Royal Gala. The efficacy was higher on the cv. Golden Delicious. 

K. M. Wasan and J. S. Conklin, Evaluation of renal toxicity and antifungal activity of free and liposomal amphotericin B following a single intravenous dose to diabetic rats with systemic candidiasis, Antimicrob. Agents Chemother. 40 1806-1810, (1996). 

Ichikawa et al. reported on the synthesis and antifungal activity of l-[(lfJ,2fi)-2-(2,4-difluorophenyl)-2-hydroxy-l-methyl-3-(l//-l,2,4-triazol-Tyl)propyl]-3-[4-(l//-l-tetrazolyl)phenyl]-2-imidazolidinone 597. Compound 597 was selected as an injectable candidate for clinical trials based on the results of evaluations of solubility, stability, hemolytic effect, and in vivo antifungal activities <2001CPB1102, 2001CPB1110>. 

Briefly, our report was the first on antiviral, antibacterial, and antifungal activities of lycoctonine, 18-O-methyllycoctonine, delcosine, 14-acetyl-delcosine, and 14-acetylbrowniine. Furthermore, our data also suggest that all of the diterpene alkaloids are worthy of being evaluated for their antimicrobial and antiviral activities for future-promising results. 

Suhr, K.l. and Nielsen, P.V. (2003) Antifungal activity of essential oils evaluated by two different application techniques against rye bread spoilage fungi. Journal of Applied Microbiology 94(4), 665-674. 

Liriodenine (70) and other oxoaporphines were evaluated for their antibacterial and antifungal activity against several micro-organisms. Only (70) showed significant activity.78... 

Singh OM, Singh SJ, Devi MB et al (2008) Synthesis and in vitro evaluation of the antifungal activities of tfihydropyrimidinones. Bioorg Med Chem Lett 18 6462-6467... 

Ashok M, Holla BS, Kumari NS (2007) Convenient one pot synthesis of some novel derivatives of thiazolo[2, 3-b]dihydropyrimidinone possessing 4-methylthiophenyl moiety and evaluation of their antibacterial and antifungal activities. Eur J Med Chem 42 380-385... 

Hemoiedemosides A (72) and B (73) from Patagonian sea cucumber Hemoidema spectabilis and their desulfated derivative 74 were evaluated for antifungal activity against Cladosporum cucumerinum [51]. Glycoside 72 showed inhibition zone of 8-33 mm at the tested concentration (1.5-50 pg/spot), while glycoside... 

Berberine chloride was evaluated for in vitro activity against Candida albicans, Cryptococcus neoformans, Mycobacterium intracellularae, Trichophyton mentagrophytes, and Saccharomyces cerevasiae, as well as representative Gram-positive and Gram-negative bacteria. The alkaloid was found to exhibit moderate to good antifungal activity, and the minimum inhibitory concentrations were determined as follows Candida albicans (0.39 pg/ml) ... 

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