Antidiabetic medications metformin

To date, the major treatments for NAFLD have been those aimed at lowering body weight and fat content. Loss of weight is often associated with decreased ALT values in one study, a 1% decrease in weight was associated with an 8% decrease in ALT activity. The association of NAFLD with insulin resistance has suggested treatment with antidiabetic medications, particularly those that increase insulin responsiveness (such as PPAR-y receptor agonists and metformin), but there are no conclusive studies that document safety and efficacy. 

The client who is obese is participating in an investigational study using metformin (Glucophage), a biguanide antidiabetic medication, for weight loss. Which data should the nurse monitor ... 

The client diagnosed with Type 2 diabetes is receiving the combination oral antidiabetic medication glyburide/metformin (Glucovance). Which data indicate the medication is effective ... 

The use of oral antidiabetic drugs may be necessary. Insuhn production is initially only moderately impaired in type 2 diabetes, so oral medication can often be used to improve insulin production (e.g. sulphonylureas), to regulate inappropriate release of glucose by the liver and attenuate insulin resistance to some extent (e.g. metformin), and to substantially attenuate insulin resistance (e.g. thiazohdinediones). A Hnal resort is insuhn therapy to maintain normal or near-normal glucose levels. 

Sensory systems Eyes Tamsulosin and other alpha-1 antagonists have been associated with intraoperative floppy iris syndrome (IFIS). A recent review compared the incidence of IFK in patients using tamsulosin and other chronic medications [35 ]. In a review of 1530 subjects who xmderwent phacoemulsification, 80% of cxn-rent tamsulosin users, 60% of previous tamsulosin users, 1% of patients on other chronic medications including antihypertensives, antipsychotics, antidiabetics and 1.7% of those on no medications at all had IFCS. The authors concluded that while IFCS was most likely associated with tamsulosin, it was also observed among patients on other chronic drugs like metformin, lisinopril and aspirin. The predisposing factors to IFCS for patients on these medications need to be elucidated. 

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