Antidiabetic medications

Fhtients with diabetes Levodopa may interfere witii urine tests for glucose or ketones. Report any abnormal result to the primary care provider before adjusting the dosage of die antidiabetic medication. 

Home blood glucose monitoring is recommended for all patients on antidiabetic medications, particularly insulin, If values are below 4mmol/L or persistently above 15 mmol/L, patients should seek immediate medical advice. Self-monitoring is usually offered to those with type 2 diabetes as an integral part of self-management education,... 

Oral antidiabetic medications are used to treat Type II diabetes mellitus by stimulating the secretion of insulin. These are ... 

How do oral antidiabetic medications treat Type n diabetes mellitus ... 

Can oral antidiabetic medications be used in place of insulin injections ... 

No. Insulin injections are administered when the pancreas is unable to product sufficient insulin. Oral antidiabetic medication stimulates insulin secretion. 

To date, the major treatments for NAFLD have been those aimed at lowering body weight and fat content. Loss of weight is often associated with decreased ALT values in one study, a 1% decrease in weight was associated with an 8% decrease in ALT activity. The association of NAFLD with insulin resistance has suggested treatment with antidiabetic medications, particularly those that increase insulin responsiveness (such as PPAR-y receptor agonists and metformin), but there are no conclusive studies that document safety and efficacy. 

The subsequent sections describe the current antidiabetic medications that are available to treat type 1 and type 2 diabetes mellitus. 

Patients who are taking antidiabetic medication may see an increase in the level of that medication when taken with chloramphenicol resulting in hypoglycemia. Therefore, diabetics who take chloramphenicol must closely monitor their blood glucose level. 

This is not a true statement. Dilantin may affect the client s antidiabetic medication. 

The client who is obese is participating in an investigational study using metformin (Glucophage), a biguanide antidiabetic medication, for weight loss. Which data should the nurse monitor ... 

The client diagnosed with Type 2 diabetes is receiving the combination oral antidiabetic medication glyburide/metformin (Glucovance). Which data indicate the medication is effective ... 

Determine when the last antidiabetic medication was administered. 

Determine if the client is currently taking any type of antidiabetic medication. 

The client with Type 2 diabetes is prescribed exenatide (BYETTA), a subcutaneous antidiabetic medication. Which information should the nurse discuss with the client ... 

An improvement in diabetic control with a reduction in dose of insulin or oral antidiabetics was seen in 6 of 7 diabetics given imat-inib for chronic myelogenous leukaemia. A further patient with type 2 diabetes was able to stop all antidiabetic medication during treatment with imatinib. 

Nicotinic acid causes a deterioration in glucose tolerance, which may be dose-related, and can result in the need for an adjustment in antidiabetic medication. Nevertheless, its benefits on lipids may outweigh its effects on glucose tolerance in some diabetics. Concurrent use should be closely monitored. 

Here, we illustrate an adaptive trial that addresses the FDA guidance for antidiabetic medications. Furthermore, we introduce a second component, not explicitly discussed in the guidance, combining the risk ratio with the risk difference, which may be appropriate when expected event rates are very small. The risk ratio/risk difference combination has been used within the phase 3 adaptive safety drug trial [17,18.]... 

Drugs should be tested as monotherapy and in combination with other antidiabetic medications with which they will likely be coadministered in clinical practice. This means that enrichment strategies may only be suitable for select study designs. As an example, participants in a monotherapy trial tend to be younger, have had diabetes for a shorter period of time, have fewer cardiovascular risk factors, and are therefore at lower risk for cardiovascular events. Enrichment in such a trial may be futile. In comparison, participants enrolled in an add-on to insulin trial are often older and have... 

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