Antidepressants Zyban

Care should be taken when prescribing other medications with clozapine. The mood stabilizer carbamazepine (Tegretol) and perhaps the antidepressant mirtazap-ine (Remeron) should not be taken with clozapine because they might further increase the risk of agranulocytosis. Likewise, the antidepressant bupropion (Wellbutrin, Zyban) should not be taken with clozapine because it may add to the seizure risk. 

Bupropion (Weiibutrin, Zyban). Bupropion is an antidepressant that is also FDA approved as a treatment for smoking cessation. It is marketed as an antidepressant as Weiibutrin and for the treatment of nicotine dependence as Zyban. Its mechanism of action in this regard is obscure, but it may act on dopamine and/or norepinephrine systems. 

Atypical Antidepressants. None of the so-called atypical antidepressants have been tested in the treatment of AN. However, mianserin, an antidepressant available in Europe, has been found to increase body weight in patients with various depressive disorders. Although bupropion (Wellbutrin, Zyban) has not been tested in the treatment of AN, it is effective in the treatment of BN. However, immediate-release bupropion is associated with an especially high risk for seizures in these patients and is therefore contraindicated in those with eating disorders. The seizure risk associated with sustained-release bupropion remains unclear at this time, as the doses studied have not been as high as those for immediate-release bupropion. 

Bupropion (Wellbutrin, Zyban). Bupropion is a newer atypical antidepressant that was initially suggested to increase both norepinephrine and dopamine activity in the brain, though controversy surrounds this hypothesis. Although bupropion has not been studied extensively in ADHD, early evidence does indeed indicate that it may be effective for both inattention and hyperactivity/impulsivity. Its effectiveness for ADHD does not appear to rival the stimulant medications, though a recent controlled study for adult ADHD showed that bupropiou outperformed placebo. 

In May 1997, GlaxoSmithKline (then known as Glaxo Wellcome, Inc.) received FDA approval to market a sustained-release version of the antidepressant Wellbutrin (bupropion hydrochloride) to smokers under the name Zyban . Today, Zyban has captured one quarter of the smoking cessation market. 

Suicidality in children and adolescents Although Zyban is not indicated for treatment of depression, it contains the same active ingredient as the antidepressant bupropion medications Wellbutrin, Wellbutrin SR, and Wellbutrin XL Antidepressants increased the risk of suicidal thinking and behavior (suicidality) in short-term studies in children and adolescents with Major Depressive Disorder (MDD) and other psychiatric disorders. Anyone considering the use of bupropion or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Closely observe patients who are started on therapy for clinical worsening, suicidality, or unusual changes in behavior. Advice families and caregivers of the need for close observation and communication with the prescriber. Bupropion is not approved for use in pediatric patients. 

FDA approves the antidepressant buproprion (Zyban) for the treatment of nicotine dependence. 

In 1996 the FDA approved the antidepressant bupro-prion (Zyban) for the treatment of nicotine dependence. This sustained-release pill blocks nicotine s pleasurable effects and helps to maintain abstinence whether the user has depression or not. The length of suggested use is for seven to 12 weeks, including one to two weeks before quitting tobacco. Buproprion doubles the quit rate and has been demonstrated to be safe when used jointly with NRT. 

The drug bupropion, sold as Wellbutrin SR and Zyban, is a prescription-only antidepressant that has been successfully used to help smokers quit. It targets the pleasure centers of the brain. Again, talk with your doctor about possibly getting a prescription to help you cope with the emotional components of quitting. 

Bupropion (Zyban), an antidepressant, to a client who has chronic obstructive pulmonary disease (COPD). 

Zyban is an antidepressant that is used to assist clients to quit smoking. It has also been shown to suppress the appetite by suppressing the uptake of norepinephrine and serotonin. 

Many noncyclic antidepressants are now available, including trazodone (Desyrel l), nefazodone (Serzone ), fluoxetine (Prozac ), sertraline (Zolotf ), citalopram (Celexa ), escitalopram (Lexapro ), paroxetine (Paxil ), tluvoxamine (Luvox ), venlafaxine (Effexor ), and bupropion (Wellbutrin ). Bupropion is also marketed under the brand name Zyban tor smoking cessation. Mirtazapine (Remeron ), a tetracyclic antidepressant, has recently become available. In general, these drugs are much less toxic than the tricyclic antidepressants (see p 90) and the monoamine oxidase (MAO) inhibitors (p 269), although serious effects such as seizures and hypotension occasionally occur. Noncyclic and tricyclic antidepressants are described in Table 11-7. 

Generic name bupropion Trade names Wellbutrin, Zyban antidepressant,... 

Bupropion, sold under the trade name of Zyban, is an antidepressant that was approved to aid smoking cessation in 1997. 

Bupropion (Zyban, Wellbutrin) (Smoking cessation aid antidepressant)... 

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