Antidepressants tianeptine

Kasper, Siegfried and Bruce S. McEwen, Neurobiological and Clinical Effects of the Antidepressant Tianeptine , CNS Drugs 22, no. 1 (2008) 15-26... 

Electrophysiological studies in the hippocampus also support enhanced al responses after chronic antidepressant treatments. Recent data indicate that the novel antidepressant tianeptine, which may increase serotonin reuptake when given chronically, also increases responsiveness of the al-adrenergic system (Rogoz et al. 2001). 

Whitehouse PJ, Price DL, Clark AW, et al Alzheimer disease evidence for selective loss of cholinergic neurons in the nucleus basahs. Ann Neurol 10 122-126, 1981 Whitehouse PJ, Price DL, Struble RG, et al Alzheimer s disease and senile dementia—loss of neurons in the basal forebrain. Science 215 1237-1239, 1982 Whitehouse PJ, Hedreen JC, White CL, et al Basal forebrain neurons in dementia of Parkinson s disease. Ann Neurol 13 243-248, 1983 Whitehouse P, Martino A, Antuono P, et al Nicotinic acetylcholine binding sites in Alzheimer s disease. Brain Res 371 146-151, 1986 Whitehouse PJ, Martino AM, Marcus KA, et al Reductions in acetylcholine and nicotine binding in several degenerative diseases. Arch Neurol 45 722-724, 1988 Whitton PS, Sama GS, O Connell MT The effect of the novel antidepressant tianeptine on the concentration of 5-hydroxytryptamine in rat hippocampal diasylates in vivo. Neuropharmacology 39 1-4, 1991 Whitworth P, Kendall DA Lithium selectively inhibits muscarinic receptor-stimulated inositol tetrakisphosphate accumulation in mouse cerebral cortex slices. J Neurochem 51 258-265, 1988... 

A review on the antidepressant tianeptine, a dibenzo[c,/]f 1,2]thiaz.epine derivative, has appeared [01CNS231],... 

In contrast to SSRIs, the atypical antidepressant tianeptine has been reported to enhance uptake of serotonin and has been proposed to act by restoring neuroplasticity (Costa e Silva, 2004). A double-blind crossover trial of tianeptine vs. placebo in 12 autistic children reported modest but statistically significant improvements after 6 weeks of treatment with respect to ABC measures of irritability, hyperactivity, inadequate eye contact, and inappropriate speech. The major side effects noted were drowsiness and decreased activity (Niederhofer et al., 2003). Larger studies of this agent in ASD populations would be useful. 

Larrey D, Tinel M, Letleron P, Mantel P, Loepta J, Belghiti J, Pessayre D (1990) Metabolic activation of the new tricyclic antidepressant tianeptine by human liver cytochrome P-450. Biochem Pharmacol 40 545-550... 

Considerable attention has been focussed on the antidepressant, tianeptine (23), which has included the development of a reverse-phase, ion-pair, liquid chromatographic method for the determination of the drug and its major metabolites in plasma, urine, and tissues <86JC115>. Further metabolic studies in healthy volunteers involving chromatographic and mass spectral analysis have also been reported <90mi 907-01 >. 

Salvador C, Ward C, Defiance R, Hopkins R. The phannacokinetics of Ihe antidepressant tianeptine and its main metabolite in healtl humans—influence of alcohol co-administiation... 

Toon S, HoltBL, Langley SJ, Mullins FGP, Rowland M, Halliday MS, Salvadori C, Delalleau B. Pharmacokinetic and pharmacodynamic interaction between the antidepressant tianeptine and oxazepam at steady-state. Psychopharmacology (Berl) (1990) 101, 226-32. 

Preskom, Sheldon H., Tianeptine A Facilitator of the Reuptake of Serotonin and Norepinephrine as an Antidepressant , Journal of Psychiatric Practice, 10, no. 5 (2004) 323-30... 

The behavioural effects of two antidepressants with opposite molecular actions, ie. tianeptine (a serotonin reuptake enhancer) and fluoxetine (a serotonin reuptake blocker) have been assessed and it was concluded that, apart from the effects on serotonin reuptake, these dmgs have other mechanisms playing an important role in the anti-depressant action <00AF5>. 

Czeh B, Michaelis T, Watanabe T, Frahm J, de Biurrun G, van Kampen M, Bartololomucci A, Fuchs E (2001) Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci U S A 98 12796-12801... 

Kato G, Weitsch AF Neurochemical profile tianeptine, a new antidepressant. Chn Neuropharmacol 11 [suppl 2) S43-S50, 1988... 

Joron, S. Robert, H. Simultaneous determination of antidepressant drugs and metabolites by HPLC. Design and validation of a simple and reliable anal3rtical procedure. Biomed.Chromatogr., 1994, 8, 158-164 [LOQ 3-17 ng/mL plasma also amitriptyline, amineptine, amoxapine, clomipramine, de-mexiptiline, desipramine, dosulepine, doxepine, doxepin, fluoxetine, fluvoxamine, imipramine, ma-protiline, medifloxamine, mianserine, opipramol, quinupramine, tianeptine, toloxatone, trazodone, trimipramine, viloxazine]... 

Tianeptine sodium is a structurally novel, serotonin specific antidepressant. It is useful in the treatment of neurotic and reactive depressions, as well as depressive states accompanied by anxiety. 

Fromenty B, Freneaux E, Labbe G, Deschamps D, Larrey D, Letteron D, Pessayre D (1989) Tianeptine, a new tricyclic antidepressant metabolized by P-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice. Biochem Pharmacol 38 3743-3751... 

Grislain L, Gele P, Bertrand M, Luijten W, Bromet N, Salvador C, Kamoun A (1990) The metabolic pathways of tianeptine, a new antidepressant, in healthy volunteers. Drug Metab Dispos 18 804-808... 

Conformational aspects of the antidepressant drug, tianeptine (23), which is a dibenzothiazepine derivative, have been studied by H and C NMR spectroscopy. Two separate conformations for the seven-membered ring are indicated at low to room temperature. The conformational preference for the side chain involves bending over the non-substituted aromatic ring moiety <92MRC1212>. 

Tianeptine, (K5)-7-(3-chloro-6-methyl-6,ll-dihydrodibenzo[c/ [l,2]lhiazepin-ll-yl-amino)heptanoic acid 5, 5-dioxide, is an antidepressant effective against anxiety accompanying mood disorders. The drug is used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. The TLC method was used to separate the photodegradation products of tianeptine [16] (Figure 14.13). 

---