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Polymers anticancer activity

Polymer Anticancer Activity and Proposed Mechanism Reference... [Pg.69]

SMANCS (Styrere-co-maleic acid/anhydride polymer bound to neocarzinostatin Neocarzinostatin (an antitumor protein) Amide bond between polymer carboxyl and protein amino None N/A SMANCS showed anticancer activity against many tumor cell lines, and had lower IC50 values than five other anticancer agents tested Liver tumors reduced more than 50% after 6 months in human subjects 15, 56, 57... [Pg.68]

DIVEMA (Hydrolyzed form of divinyl ether and maleic anhydride copolymer) Cyclophos- phamide Ester bond between drug derivative hydroxyl and polymer carboxyl None N/A N/T Anticancer activity of conjugate was comparable to free drug against L1210 leukemia bearing mice 58... [Pg.68]

Table 2. Polymers with intrinsic anticancer activity... Table 2. Polymers with intrinsic anticancer activity...
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See also in sourсe #XX -- [ Pg.65 , Pg.66 , Pg.67 , Pg.68 , Pg.69 ]



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