Antibiotics rationale

In spite of the rationale on which the testing of dyestuffs as antibiotics rested subsequent research re vealed that the antibacterial properties of Prontosil had nothing at all to do with its being a dye In the body Prontosil undergoes a reductive cleavage of its azo linkage to form sulfanilamide which is the sub stance actually responsible for the observed biological activity This is why Prontosil is active in vivo but not in vitro... 

Antibiotics have been studied based on the rationale that they may interrupt the inflammatory response directed against endogenous bacterial flora. Metronidazole and ciprofloxacin have been the two most widely-studied agents.32 Metronidazole may benefit some patients with pouchitis (inflammation of surgically-created intestinal pouches) and patients with CD who have had ileal resection or have perianal fistulas. Ciprofloxacin has shown some efficacy in refractory active CD. Both drugs may cause diarrhea, and long-term use of metronidazole is associated with the development of peripheral neuropathy. 

Rationale. Microorganisms were isolated from soil and screened for toxin production according to the scheme in Figure 1. Some of the organisms causing strong inhibition on solid medium were tested for toxin production in liquid medium. Liquid culture will be required to obtain large amounts of material for commercial production of herbicides, however, the ability to produce toxins on solid medium does not necessarily imply toxin production in broth (34). Cyclo-heximide, a phytotoxic but relatively nonspecific antibiotic with little value as a herbicide, is produced by many actinomycetes. Liquid cultures were tested for cycloheximide to determine whether it caused the observed toxicity. 

A range of thiolactones was obtained by virtual screening with the rationale to be covalently cleaved by FabDSer92. Among them, 4 was described as a potent E. coli FabD inhibitor with antibiotic properties although no further biological data was provided [12]. 

Antibiotics are commonly used in the treatment of inflammatory complications of diverticular disease [3, 24]. In painful diverticular disease, when inflammation is excluded by definition, there is no rationale for using antibiotics. In a subset of patients with more severe symptoms, when an inflammatory component may be clinically suspected, a short course of antibiotics may be advisable [15],... 

Aminoglycoside antibiotics are frequently used in combination with the -lactam antibiotics. Which of the following choices best explains the rationale for this use ... 

Drug Iodine Principal Indication(s) Adhesive capsulitis and other soft-tissue adhesions microbial infections Treatment Rationale Iodine is a broad-spectrum antibiotic, hence its use in infections, etc. the scle-rolytic actions of iodine are not fully understood Iontophoresis 5°/o-10°/o solution or ointment from negative pole Phonophoresis 10% ointment... 

Though the rationale of antimicrobial approaches to treatment is evident, their limitations have also been evident. With systemic therapy, it may be difficult to achieve bacteriostatic or bactericidal antibiotic concentrations in pockets without using doses that evoke systemic side effects. The development of bacterial resistance is also an issue. The rise of antibiotic resistant, disease-producing bacterial strains is currently a... 

Chemical name and the structural formula of each active ingredient compedial name as well as company codes and other appropriate identifications. Where chemical structure is not available, a rationale of the selection of the type of compound, e.g., antibiotics, must be made. 

These considerations provide a strong argument and rationale for discovery and development of inhibitors of RND transporters from Gram-negative bacteria that could be used in conjunction vdth antibiotics. Such inhibitors would increase antibacterial potency, expand the spectrum of antibacterial activity, reverse resistance... 

Riley LH 3d. Prophylactic antibiotics for spine surgery Description of a regimen and its rationale. J Soufii Orthop Assoc 1998 7 212-217. 

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