Antibiotics interaction

Fritzsche H, Wahnert U, Chaires JB, Dattagupta N, Schlessinger IT5, Crothers DM (1987) Anthracycline antibiotics. Interaction with DNA and nucleosomes and inhibition of DNA synthesis. Biochemistry 26(7) 1996-2000... 

Archer JS, Archer DF. Oral contraceptive efficacy and antibiotic interaction a myth debunked. J Am Acad Dermatol 2002 46(6) 917-23. 

Poehlsgaard J, Douthwaite S. Macrolide antibiotic interaction and resistance on the bacterial ribosome. Curr Opin Investig Drugs. 2003 4 140-148. 

Ribosomal RNAs (rRNAs) play an active structural role in ribosomes that are essential components of the cellular protein synthesis machinery. rRNAs are also believed to participate in tRNA binding, ribosomal subunit association, and antibiotic interactions. In a typical eukaryotic cell, there are four types of rRNA (28S, 18S, 5.8S, and 5S) that vary in size and sequence,... 

Fig. 4.4 Secondary structure of the PTC and antibiotic information. Nucleotide numbering is from H. marismortui (Hm) and is followed by the standard corresponding coli (Ec) numbering in parentheses. Nucleotides with superscripts have been implicated in antibiotic interactions by nucleotide protection studies (green) [54-57] or by mutations (orange) that confer resistance to carbomycin A (M) linco-samides (L) streptogramin A [58] (S) chlor-...

Rhodes KM, Brown SN. Do the penicillin antibiotics interact with digoxin Eur J Chn Pharmacol 1994 46(5) 479-80. 

S. C. Kinsky, Antibiotics interaction with model membranes, Anna. Rev. Pharmacol., 10 (1970) 119-142. 

Llano-Sotelo, B. Chow, C. S., RNA-aminoglycoside antibiotic interactions fluorescence detection of binding and conformational change, Bioorg. Med. Chem. Lett. 1999, 9, 213-216... 

As stated in Section II.B, macrolide antibiotics interact with peptidyltransferase by forming hydrogen bonds usually but occasionally hydrophobic bonds present in a 508 ribosomal subunit. That is why noncovalent interactions appear to be the key to the antibiotic flexibility and specificity observed between different macrolides and their derivatives and also probably to the solubility of the drugs in water. 

In terms of the basic principle of the secondary structure, E. coli 23S rRNA has six domains [166]. Macrolide antibiotics interact with two regions (in domains II and V) of 23S rRNA [166-168], and domain V plays a particularly important role on the occasion of translation, that is, during the peptidyltransferase reaction [26, 27, 98-100, 169]. 

The inhibition of the prokaryotic translation and not that of the eukaryote can result from differences between their respective ribosomes. Some antibiotics interact with the RNA components that are unique to bacterial ribosomes and, consequently, can inhibit bacterial growth without affecting the human cells. 

Stanley JC, Mirakhur RK, Clarke RSJ. Study of pipecuronium-antibiotic interaction. An-es tesiology (1990) 73, A898. 

Paradelis AG, Crassaris LG, Karachalios DN, Triantapl llidis CJ. Aminoglycoside antibiotics interaction with trimethaphan at the neuromuscular junctions. Drugs Clin Res (1987)... 

ADRAC. Fluoroquinolone antibiotics interactions with warfarin. Aust Adverse Drug React... 

Katz ME, Cassileth PA (1977) Disseminated candidiasis in a patient with acute leukemia, successful treatment with miconazole. JAMA 237 1124-1125 Kinsky SC (1970) Antibiotic interaction with model membranes. Annu Rev Pharmacol 10 119... 

Egebjerg j, Douthwaite S, Garrett RA. Antibiotic interactions at the GTPase.associaied centre within Escfiericliui coti 23S rRNA. EMBO J 1989 8 607-611. 

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