Synergistic interaction with polyene antibiotics

Attempts have been made to reduce the systemic toxicity of polyenes by replacing part of the polyene dose with alternative antimicrobial agents. These in vitro experiments show some promise for the chemotherapy of stemic mycoses. 

In elderly males, benign hypertrophy of the prostate is of great clinical importance. It results in urinary obstruction, secondary changes in the urinary tract due to back pressure and risks of secondary infection. Chemotherapy of this condition is attractive as surgery is not always practicable in elderly. patients. 

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