Antibiotics future trends

H. Zaehner F. P. Fiedler, Fifty Years of Antimicrobials Past Perspectives and Future Trends. In The Need for New Antibiotics Possibiy Ways Forward (53rd Symposium of the Society for Generai Microbioiogy)] P. A. Hunter, G. K. Darby, N. J. Russell, Eds. Cambridge University Press Cambridge, 1995 pp 67-84. 

Sanchez, S. and Demain, A.L. (eds) (2016) Antibiotics Current Innovations and Future Trends, Caister Academic Press. 

Zahner, H., Fielder, H. P. The need for new antibiotics possible ways forward. In Fifiy Years of Antimicrobials Past Perspectives and Future Trends, Hunter, P. A., Darby, G. K., Russell, N. J. (Eds.), CambridgeUniveisily Press Cambridge, UK, 1995, pp. 67-83. 

However, disinfectant household cleaners are also more likely now to be mentioned in newspaper and magazine articles as contributing to the problems of antibiotic-resistant bacteria these tend to be reports in the popular press where all antimicrobial products tend to be mentioned, despite no demonstrated scientific link between the household cleaner disinfectants and the problem [172-174], As noted, disinfectant cleaners continue to have popularity, but given some of the trends in microbial control issues, they may be either more heavily regulated or limited in the future. 

Another current trend that is well underway is the use of more specific analytical instrumentation that allows less extensive sample preparation. The development of mass spectrometric techniques, particularly tandem MS linked to a HPLC or flow injection system, has allowed the specific and sensitive analysis of simple extracts of biological samples (68,70-72). A similar HPLC with UV detection would require significantly more extensive sample preparation effort and, importantly, more method development time. Currently, the bulk of the HPLC-MS efforts have been applied to the analysis of drugs and metabolites in biological samples. Kristiansen et al. (73) have also applied flow-injection tandem mass spectrometry to measure sulfonamide antibiotics in meat and blood using a very simple ethyl acetate extraction step. This important technique will surely find many more applications in the future. 

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