Antibiotics controlled release

Lira, L. M. Cordoha de Torresi, S. I. Polymeric electro-mechanic devices applied to antibiotic-controlled release. Sens. Actuators, B 2008, B130, 638-644. 

CONTROLLED RELEASE TECHNOLOGY - PHARMACEUTICAL] (Vol 7) -bacitracin treatment of [ANTIBIOTICS - PEPTIDES] (Vol 3)... 

Microcapsules can be used for mammalian cell culture and the controlled release of drugs, vaccines, antibiotics and hormones. To prevent the loss of encapsulated materials, the microcapsules should be coated with another polymer that forms a membrane at the bead surface. The most well-known system is the encapsulation of the alginate beads with poly-L-lysine. 

Lor the second type of dmg release from depots, ELPs were crosslinked prior to implantation. In an investigation on the controlled release of the antibiotics... 

In the above trial [70] rifaximin was dissolved in chloroform and applied by repeated painting. After the solvent had dried a red sludge persisted over the dental structures allowing a continuous antimicrobial effect. Better delivery systems, such as subgingival controlled release preparations [12], are, however, needed to fully exploit the rifaximin potential in periodontal disease. In this connection, a gum-like device [71] has been developed that allows a controlled and continuous release of the antibiotic within the oral cavity. Large double-blind controlled trials using this and other formulations are now needed to establish the best therapeutic regimen for this indication. 

Godin, B., E. Rubinstein, and E. Touitou. 2004. A new approach to interfere with microorganisms resistance to antibiotics, 31st Annual Meeting and Exposition of the Controlled Release Society, Honolulu, Hawaii, 354. 

Zilberman M, Eisner JJ (2008) Antibiotic-eluting medical devices for various applications. J Control Release 130 202-215... 

Suzuki Y, Tanihara M, Nishimura Y et al. (1998) A new drug delivery system with controlled release of antibiotic only in the presence of infection. J Biomed Mater Res 42 112-116... 

Xanthate-modified cellulose binds metal-TC tetracycline complexes and is evaluated to be an effective controlled release system for TCs complexes, owing to the metal-binding properties of these antibiotics. ... 

Risbud, M.V. Hardikar, A.A. Bhat, S.V. Bhonde, R.R. pH-sensitive freeze-dried chitosan-polyvinyl pyrrohdone hydrogels as controlled release system for antibiotic delivery. J. Control. Release 2000, 68, 23-30. 

Suzuki, Y. Tanihara, M. Nishimura, Y. Suzuki, K. Kakimaru, Y. Shimizu, Y. A new drug dehvery system 124. with controlled release of antibiotic only in the presence... 

No. 12, June 1997, p.839-44 CONTROLLED RELEASE OF ANTIBIOTICS FROM BIOMEDICAL POLYURETHANES MORPHOLOGICAL AND STRUCTURAL FEATURES... 

D. Sendil, 1. Guresel, D. L. Wise, V. Hasirci Antibiotic release from biodegradable PHBV microparticles. J. Control. Release, 59, 207 (1999). 

Y. Zhang, M. Zhang Calcium phosphate/chitosan composite scaffolds for controlled in vitro antibiotic drug release. J. Biomed. Mater. Res. 62, 378 (2002). 

PEG-based copolyesters possess the ability to serve as absorbable controlled release carriers for a whole host of bioactive agents. The ability to provide a means of local therapy with systemically toxic agents directly at the site of interest has heightened awareness of these PEG-based systems. In addition, since these copolymers are absorbable, they allow for local drug delivery without the inherent risks associated with permanent foreign bodies. Some applications of the PEG-based systems include, but are not limited to, antibiotic formulations for osteomyelitis, controlled release of vaccines, intra-vaginal delivery of misoprostol, periodontal application of antibiotics, and intraocular drug delivery. 

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