Controlled release of antibiotics from

No. 12, June 1997, p.839-44 CONTROLLED RELEASE OF ANTIBIOTICS FROM BIOMEDICAL POLYURETHANES MORPHOLOGICAL AND STRUCTURAL FEATURES... 

Schierholz JM, Steinhauser H, Rump AFE, Berkels R, Pulverer G. Controlled release of antibiotics from biomedical polyurethanes morphological and structural features. Biomaterials 1997 18 839. http //dx.doi.org/10.1016/S0142-9612(96)00199-8. 

Murugan, R. and Rao, K.R (2002). Controlled release of antibiotic from surface modified corafiine hydroxyapatite. Trends Biomater. Artif. Organs 16 43-5. 

Lewis, D. H., Dappert, T. O., Meyers, W. E., Pritchett, G., and Suling, W. J., Sustained release of antibiotics from biodegradable microcapsules, Proc. Int. Symp. Control. Rel. 

Plasma-Deposited Membranes for Controlled Release of Antibiotic to Prevent Bacterial Adhesion and Biofilm Formation. Journal of Biomedical Materials Research, Vol. 50, No. 2, (February 2000), pp. (160-170), ISSN1552-4%5 Hirst, A.R., Escuder, B., Mravet, J.F. Smith, D.K (2008). High-Tech Applications of Self-Assembling Supramolecular Nanostructured Gel-Phase Materials From... 

Y. Ikada, S.-H. Hyon, K. Jamshidi, S. Higashi, T. Yamamura, Y. Katutani and T. Kitsugi, "Release of antibiotic from composites of hydroxyapatite and poly(lactic acid)", J. Control. Rel., 2,179-186,1985. 

Lor the second type of dmg release from depots, ELPs were crosslinked prior to implantation. In an investigation on the controlled release of the antibiotics... 

J. Kazuhiko, N. Masahiro, and K. Miho, Controlled release of aclarubicim, an anti cancer antibiotic, from poly-P-hydroxybutyric acid microspheres, J. Controlled Release, 4(1), 25-32, 1986. 

Ocular systems (Figure 7.5b) with application in the lower ophthalmic conjunctival sac for the controlled release of ciprofloxacin (pre- or post-operative treatment of topical infections, as well as conjimctivitis) were obtained from polyvinyl alcohol and sodium carboxymethylcellulose linking the two polymers by an esterification reaction between the hydroxyl groups of the polyvinyl alcohol and carboxyl groups of carboxy-methyl cellulose [47]. Membranes were obtained by the incorporation of the antibiotic into the polymer solution with the addition of glycerol as a plasticizer (in order to ensure the flexibility of the membrane). The advantage of using these polymers comes from their biocompatibility and from the fact that they are water soluble as the controlled release occms, the membrane is dissolved by the tear bed at 35"C temperature. 

Frequently, the constant release of a drug from pharmaceutical dosage forms enables one to obtain a suitable pharmacological and therapeutic response. However, for therapy of certain pathologies, i.e. some heart and rheumatic diseases, or in the utilization of some drags such as contraceptive steroids and antibiotics, it would be more useful to obtain different plasma levels of the active principle at different times related to painful symptoms or circadian rhythms, etc. In these cases the desired therapeutic results can usually be obtained with frequent administration of conventional dosage forms which lead to a prompt absorption of the active principle. This kind of drag treatment is often compromised by a lack of full compliance by the patient. Until now there have been few systems that allow the release of the active principle in successive pulses at precise and well-controlled time periods [11,12]. 

---