Antiarrhythmics amiodarone

If the compound is virtually insoluble (solubility mixed solvent approach can be tried [2, 28-30]. For example, the pka of the antiarrhythmic amiodarone, 9.06 0.14, was estimated from water-methanol... [Pg.60]

Drugs that may affect nelfinavir include anticonvulsants, azithromycin, azole antifungals, efavirenz, delavirdine, HMG-CoA reductase inhibitors, indinavir, interleukins, nevirapine, rifabutin, rifampin, ritonavir, saquinavir, St. John s wort. Drugs that may be affected by nelfinavir include amiodarone, antiarrhythmics (amiodarone, quinidine), azithromycin, benzodiazepines, efavirenz, ergot alkaloids, delavirdine, didanosine, fentanyl, indinavir, lamivudine methadone, nonsedating antihistamines, oral contraceptives, phenytoin, pimozide, quinidine, rifabutin, saquinavir, sildenafil, sirolimus, tacrolimus, zidovudine. [Pg.1820]

During the last decades several drugs and compounds have been identified that to different degrees are able to overcome MDR so that the cells resemble sensitive cells in their chemosensitivity. These drugs mainly include catamphiphilic, membrane-active compounds and belong to various classes of drugs such as calcium channel blockers (verapamil), neuroleptics (flupentixol), anesthetics, antimalarial drugs (quinidine), antiarrhythmics (amiodarone), and many other compounds. Reviews were recently published [61, 157]. [Pg.246]

POTASSIUM-SPARING DIURETICS ANTIARRHYTHMICS -AMIODARONE Risk of T levels of eplerenone with amiodarone risk of hyperkalaemia directly related to serum levels Amiodarone inhibits CYP3A4-mediated metabolism of eplerenone Restrict dose of eplerenone to 25 mg/day. Monitor serum potassium concentrations closely watch for hyperkalaemia... [Pg.112]

IVABRADINE ANTIARRHYTHMICS - AMIODARONE, DISOPYRAMIDE Risk of arrhythmias Additive effect Monitor ECG closely... [Pg.119]

ANION EXCHANGE RESINS ANTIARRHYTHMICS -AMIODARONE Colestyramine 1 amiodarone levels Colestyramine binds amiodarone, reducing its absorption and interrupting its enterohepatic circulation Avoid co-administration... [Pg.121]

SIMVASTATIN ANTIARRHYTHMICS- AMIODARONE t risk of myopathy with high doses (>40mg) of simvastatin coadministered with amiodarone Uncertain amiodarone inhibits intestinal P-gp, which may t the bioavailability of statins Avoid >20 mg doses of simvastatin in patients taking amiodarone if higher doses are required, switch to an alternative statin... [Pg.125]

LITHIUM ANTIARRHYTHMICS -AMIODARONE 1. Rare risk of ventricular arryth-mias, particularly torsades de pointes 2. Risk of hypothyroidism 1. Additive effect lithium rarely causes Q-T prolongation 2. Additive effect both drugs can cause hypothyroidism 1. Manufacturers of amiodarone recommend avoiding co-administra-tion 2. If co-administration thought to be necessary, watch for symptoms/ signs of hypothyroidism check TFTs every 3-6 months... [Pg.156]

VENLAFAXINE 1. ANTIARRHYTHMICS - amiodarone, disopyramide, procainamide, propafenone 2. ANTIBIOTICS — macrolides (especially azithromycin, clarithromycin, parenteral erythromycin, telithromycin), quinolones (especially moxifloxacin), quinupristin/ dalfopristin 3. ANTICANCER AND IMMUNOMODULATING DRUGS -arsenic trioxide 4. ANTIDEPRESSANTS-TCAs 5. ANTIEMETICS-dolasetron 6. ANTIFUNGALS-fluconazole, posaconazole, voriconazole 7. ANTIHISTAMINES-terfenadine, hydroxyzine, mizolastine 8. ANTIMALARIALS -artemetherwith lumefantrine, chloro-quine, hydroxychloroquine, mefloquine, quinine 9. ANTIPROTOZOALS -pentamidine isetionate 10. ANTIPSY-CHOTICS - atypicals, phenothiazines, pimozide 11. BETA-BLOCKERS -sotalol 12. BRONCHODILATORS-parenteral bronchodilators 13. CNS STIMULANTS - atomoxetine Risk of ventricular arrhythmias, particularly torsades de pointes Additive effect these drugs cause prolongation of the Q-T interval Avoid co-administration... [Pg.196]

PHENYTOIN ANTIARRHYTHMICS -AMIODARONE Phenytoin levels may be t by amiodarone conversely, amiodarone levels may be 1 by phenytoin Uncertain amiodarone inhibits CYP2C9, which plays a role in phenytoin metabolism, while phenytoin is a known hepatic enzyme inducer. Also, amiodarone inhibits intestinal P-gp, which may t bioavailability of phenytoin 1 phenytoin dose by 25-30% and monitor levels watch for amiodarone toxicity. Note that phenytoin and amiodarone share similar features of toxicity, such as arrhythmias and ataxia... [Pg.221]

ORLISTAT ANTIARRHYTHMICS -AMIODARONE Possible 1 amiodarone levels i absorption of amiodarone Watch for poor response to amiodarone... [Pg.236]

ANALGESICS-celecoxib, opioids 2. ANTIARRHYTHMICS -amiodarone, flecainide, propafenone 3. ANTICANCER DRUGS - doxorubicin... [Pg.280]

PORFIMER I. ACE INHIBITORS -enalapril 2. ANALGESICS -celecoxib, ibuprofen, ketoprofen, naproxen 3. ANTIARRHYTHMICS — amiodarone 4. ANTIBIOTICS -ciprofloxacin, dapsone, sulphonamides, tetracyclines 5. ANTICANCER AND IMMUNOMODULATING DRUGS -fluorouracil (topical and oral) 6. ANTIDIABETIC DRUGS-glipizide 7. ANTIMALARIALS -hydroxychloroquine, quinine 8. ANTIPSYCHOTICS -chlorpromazine, fluphenazine 9. CALCIUM CHANNEL BLOCKERS - diltiazem 10. DIURETICS -bumetanide, furosemide, hydrochlorothiazide II. PARA-AMINOBENZOIC ACID (TOPICAL) 12. RETINOIDS-acitretin, isotretinoin 13. SALICYLATES (TOPICAL) t risk of photosensitivity reactions Attributed to additive effects Avoid exposure of skin and eyes to direct sunlight for 30 days after porfimer therapy... [Pg.333]

THYROID HORMONES ANTIARRHYTHMICS -AMIODARONE Risk of either under- or overtreatment of thyroid function Amiodarone contains iodine and has been reported to cause both hyper- and hypothyroidism Monitor triiodothyronine, thyroxine and TSH levels at least 6-monthly... [Pg.456]

INHALATIONAL ANTIARRHYTHMICS -AMIODARONE Amiodarone may t myocardial depressant effects of inhalational anaesthetics Additive effect Monitor PR, BP and ECG closely... [Pg.494]

CIMETIDINE, RANITIDINE ANTIARRHYTHMICS-AMIODARONE, FLECAINIDE, MEXILETINE, PROCAINAMIDE, PROPAFENONE Likely t plasma concentrations of these antiarrhythmics and risk of adverse effects Cimetidine inhibits CYP2D6-mediated metabolism of flecainide, mexiletine, procainamide and propafenone. Ranitidine is a much weaker CYP2D6 inhibitor. Cimetidine is a potent inhibitor of organic cation transport in the kidney, and the elimination of procainamide is impaired Monitor PR and BP at least weekly until stable. Warn patients to report symptoms of hypotension (lightheadedness, dizziness on standing, etc.). Consider alternative acid suppression therapy... [Pg.638]

AGALSIDASE BETA ANTIARRHYTHMICS -AMIODARONE 1 clinical effect of agalsidase beta Uncertain Avoid co-administration... [Pg.676]

AMPHETAMINES ANTIARRHYTHMICS -AMIODARONE t plasma concentrations of amphetamine, with risk of toxic effects Due to inhibition of CYP2D6-mediated metabolism of amphetamine Avoid concurrent use... [Pg.699]

Cardiac antiarrhythmics. Amiodarone, propafenone and possibly quinidine potentiate the effect of warfarin and dose adjustment is required, but atropine, disopyramide and lignocaine do not interfere. [Pg.572]

Although officially classified as a class III antiarrhythmic, amiodarone possesses electrophysiologic characteristics of all four Vaughn Williams classifications. Acutely, intravenous amiodarone displays mainly antiadrenergic (class II) and calcium channel blocking (class TV) properties. Consequently, hypotension, which occurs in roughly 20% of clinical trials, is a concern. This hypotension is more dependent on the rate of administration than on the amount of drug... [Pg.177]

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