Antiaging treatments

Formulations of hydrogels and liopgels with vitamin E have been reported for use in cosmetics as a locally acting antiaging treatment because of the antioxidant effects of vitamin E. The formulation consists of olive oil and hydrogels containing 2% tocopherol (161). 

Whether there is any other connection between anticonvulsant activity and camosine s antiaging actions is obviously highly speculative. It may be relevant to note that epileptic seizures and a shortened life span, together with altered protein accumulation, are consequences of PIMT-deficiency in mice, while treatment with valproic acid, an anticonvulsant, partially suppresses these symptoms including effects on life span (Yamamoto et ah, 1998). Conversely, PIMT overexpression can increase life span of Drosophila (Bennet et ah, 2003). Furthermore, the chemistry of some anticonvulsants (ethosuximide) resembles quite closely the structure of the succinimide intermediate formed during both asparagine deamidation and PIMT-mediated repair of isoaspartate residues. One conjectures whether there are any relationships between these... 

Hypercholesterolemia - [ANTIAGING AGENTS] (Vol 2) - [DIURETIC AGENTS] (Vol 8) - [PHARMACODYNAMCS] (Vol 18) -in transgenic mice [GENETIC ENGINEERING - ANIMALS] (Vol 12) -treatment of [CARDIOVASCULARAGENTS] (Vol 5)... 

The effects of treatment with selegiline, an MAO-B inhibitor, on plasma levels of insulin-like growth factor I (IGF-I) (as indicator of GH secretion), levels of monoamines and their metabolites, and the activity and content of tyrosine hydroxylase — the rate-limiting enzyme in the biosynthesis of catecholamines — in the hypothalamus and hypophysis of old animals have been studied. It is believed that the antiaging effects of selegiline are due to restoration of hypothalamic hormones. 

Lactic acid, as well as being a component of the NMF, is also a member of the class of molecules called alpha hydroxy acids (AHAs), which exert specific and unique benefits on skin structure and function. Although originally described for the treatment of dry skin-related disorders, their pleiotropic properties include influencing skin cell renewal and other antiaging benefits, which have become the focus of considerable interest in recent years. 

Table 3.8. Antiaging effect of (-)-deprenyl treatment. Data taken from Table 4 in Knoll (1989). Details explained in text...

Table 3.10 shows that (-)-deprenyl, injected subcutaneously three times a week for 18 months, prevented the age-related morphological changes of the pigment granules in the neurocytes of the substantia nigra of rats. This is morphological evidence for the antiaging effect of prophylactic treatment with a synthetic mesencephalic enhancer substance. 

Ascorbosilane C. [Exsymd] Ascorbyl meihylsilanol pecdnate increases c membrane resistance for skin maintenance and tissue regeneration in antiaging, after sun bath, and bum treatment ftxmuladons. 

Based on a wide range of pharmacological effects and its history, and safety, curcumin has significant potential for use in cosmetic products. As an anti-inflammatory, it has been used in antiaging products. It is commonly used as a natural colorant (27), but has also found numerous uses as an antiseptic, in the prevention of dry skin, in the treatment of eczema and acne and the slowing down of wrinkles and aging. Turmeric and curcumin are found in facial masks, washes, lip balms, and sunscreens. Clinical supports of these label... 

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