Windaus, Adolf

WINDAUS, ADOLF (1876-1959). A German chemist who won the Nobel prize for chemistry in 1928. His work involved the study of steroids and the effect of ultraviolet light activity, ergosterol, and vitamin D2. He also researched digitalis and histamine. Although he studied medicine, he received his doctorate in chemistry at the University of Freiburg. 

WIndaus, Adolf Otto Reinhold (1876-1959) German biochemist who studied the drug digitalis, established the structure of cholesterol, and researched vitamin D and some of the B vitamins. He was awarded the 1928 Nobel Prize in chemistry. 

Adolf Windaus research into the constitution of the sterols and the connection with the vitamins... 

Adolf Windaus Germany sterols relationship with vitamins... 

Adolf Windaus (1867-1959), German chemist, receives the Nobel Prize in chemistry for his research of the sterols and their connection with vitamins. 

Two German chemists, Heinrich Otto Wieland (1877-1957) and Adolf Windaus (1876-1959), each received a Nobel Prize in chemistry (Wieland in 1927 and Windaus in 1928) for work that led to the determination of the structure of cholesterol. 

Adolf Windaus originally intended to be a physician, but the experience of working with Emil Fischer for a year changed his mind. He discovered that vitamin D was a steroid, and he was the first to recognize that vitamin Bj contained sulfur. 

Two German chemists, Heinrich Otto Wieland (1877-1957) and Adolf Windaus (1876- ), worked out the structure of steroids and related compounds. (Among the steroids are a number of important hormones.) Another German chemist, Otto Wallach (1847-1931), painstakingly elucidated the structure of terpenes, important plant oils (of which menthol is a well-known example), while still another, Hans Fischer (1881-1945), established the structure of heme, the coloring matter of blood. 

Adolf Otto Reinhold Windaus (Germany) for his research into the constitution of the sterols and their connection with the vitamins. Windaus was awarded the Nobel Prize for discovering that cholesterol (a sterol) was removed to cholecalcif-erol (vitamin D3) through a series of several steps. One of Windaus doctoral students, Adolf Buteneindt, was himself a Nobel laureate. 

Our study of the literature had shown that the nonsaponifiable moiety of fats could form compounds with cyanic acid—the so-called allophanates. They had been known from the days of Liebig and Wohler (1830), and in some of his studies of vitamin D had been employed by Windaus at Goettingen, whither went our Dr. and Mrs. Emerson in the fall of 1932, to gain the warm friendship of this chief and his brilliant young colleague Adolf Butenandt. 

The beginnings of steroid chemistry go back to Adolf Windaus (1876-1959), who laid the foundations of this captivating field in 1905. Important contributions came from Adolf Butenandt (1903-1995) and Heinrich Otto Wieland (1877-1957). [15] Oestrone was the first sex hormone to he isolated from the urine ofpregnant women in 1929 hy Butenandt in Gottingen. [16] Later,heused... 

This material was also detectable in crude cholesterol from animals. Later it was found, that irradiation of ergosterol, a steroid from baker s yeast, led to a mixture of products with extraordinarily high anti-rachitic activity. At the end of the 1920s, Otto Rosenheim, Thomas Arthur Webster and Adolf Windaus succeeded, independently of each other, in isolating first the unpurified Vitamin D (Vitamin Dj, a mixture of ergocalciferol and lumisterolj) and later the pure crystalline Vitamin D (Vitamin D2, ergocalciferol). The structure determination followed by classical chemical degradation. 

Hans Brockmann (1903-1988) isolated Vitamin D3 from tuna liver oU. The synthesis was achieved by irradiation of 7-dehydrocholesterol, a minor component of crude cholesterol. Adolf Windaus (1876-1959) and Sir Ian Morris Heilbron (1886-1959) determined the structure and Hans Herloff Inhoffen (1906-1992) confirmed it by total synthesis. 

Cholesterol was first isolated in 1770. In the 1920s, two German chemists, Adolf Windaus (University of Gottingen) and Heinrich Wieland (University of Munich), were responsible for outlining a structure for cholesterol they received Nobel prizes for their work in 1927 and 1928. ... 

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