Anti-leukemic

Zee-Cheng KY, Cheng CC. Common receptor-complement feature among some anti-leukemic compounds. J Pharm Sci 1970 59 1630-4. 

The histone deacetylase inhibitor ITF2357 has anti-leukemic activity in vitro and in vivo and inhibits IL-6 and VEGF production by stromal cells. Leukemia,... 

Loss of the p53 tumor suppressor gene has been shown to impede the anti-leukemic response to BCR-ABLl inhibition (43). Another mechanism for resistance that is independent of BCR-ABLl and that has been demonstrated in vitro is over-expression of SRC-related kinases such as LYN (44). It appears that kinases from the SRC family mediate signaling of BCR-ABLL This has been demonstrated in vitro with the use of SRC kinase inhibitors and SRC mutants that are kinase defective (45,46,47). 

Gonzalez IC, Forsyth CJ (2000) Total Synthesis of Thyrsiferyl 23-Acetate, a Specific Inhibitor of Protein Phosphatase 2A and an Anti-Leukemic Inducer of Apoptosis. J Am Chem Soc 122 9099... 

Extracts of Amaryllidaceae alkaloids have long been used in traditional medicine for the treatment of a variety of illnesses. As early as the fourth century B.C., Hippocrates had reputedly advised the use of preparations of Amaryllidaceae plants to control uterine tumours [157]. More recently, a systematic bioassay of these alkaloids of different structural types has revealed a diversity of interesting biological properties. Thus, (+)-pretazettine (369) [158,159], and ungeremine (182) [160] show anti-leukemic activity. Cytotoxicity was observed for (-)-lycorine (245) [161], (-)-pseudolycorine (574) [162], 6-a-hydroxycrinamine (575) [163],... 

Furlong MT et al (2012) A validated LC-MS/MS assay for the simultaneous determination of the anti-leukemic agent dasatinib and two pharmacologically active metabolites in human plasma application to a clinical pharmacokinetic study. J Pharm Biomed Anal 58 ... 

The carbene-insertion pathway has recently been applied in total asymmetric syntheses of the anti-leukemic alkaloid, (—)-agelastatin A, and the dibromo analog, (-)-agelastatin B (02JA9060, 02JOC7096). Treatment of the (oxazolidinonyl)propynyliodonium triflate 250 with sodium />-toluenesulfinate leads to a mixture of the bicyclic oxazolidinone 251 and the carbenic rearrangement product 252 (Scheme 70) compound 251 is a key intermediate in the agelastatin synthesis. 

Shadidi, M. and M. Sioud (2001). An anti-leukemic single chain Fv antibody selected from a synthetic human phage antibody library. Biochem Biophys Res Commun 280(2) 548-552. 

G. Klopman and O. T. Macina, Mol. Pharmacol., 31, 457 (1987). Computer-Automated Structure Evaluation of Anti-leukemic 9-Anilinoacridines. 

Jones RJ, Sharkis SJ, Miller CB, Rowin-sky EK, Burke PJ, May WS. 1990. Bryostatin 1, a unique biologic response modifier anti-leukemic activity in vitro. Blood 75 1319-23... 

PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect. Leukemia 25 606-614... 

Usnic acid (7.53)—a highly biologically active dibenzofuran—is a phenol oxidation product of an acylphlorogludnol. It is produced by numerous lichens, including several Usnea species. Apart from its antibiotic and anti-leukemic activity, it has insect anti-feedant activity. Its presence may account for the observation that many lichens are resistant to serious insect attack. 

Myers, D., Yanishevski, Y., Masson, E., Irvin, J., Evans, W., and Uckun, F. (1995) Favorable pharmacodynamic features and superior anti-leukemic activity of B43 (anti-CD19) immunotoxins containing two pokeweed antiviral protein molecules covalently linked to each monoclonal antibody molecule. Leuk. Lymphoma 18, 93-102. 

NR Ferringi, JL McLaughlin, RG Powel, CR Smith. Use of potato disk and brine shrimp bioassay to detect activity and isolate piceatanol as the anti-leukemic principle from the seeds of Euphobia lagascae. J Nat Prod Al 347-352, 1984. 

Table 8. Anti leukemic Activity of Bisbrusatolyl and Brusatolyl Esters and Related Compounds against P>388 Lymphocytic Leukemia Cell Growth in BDFl Mice...

See, for example, Andrivon, W., et ai. A new anthracycline with potent anti-leukemic activity overcomes P-glycoprotein multidrug resistance. Leuk. Res. 1998, 22, 719-725. 

Find the full chemical name, the drug name, and chemical structure of the anti-leukemic developed by Hitchings and Elion. 

Kupchan, S. M., a. L. Desserttne, B. T. Blaylock, and R. F. Bryan, Isolation and stmcture elucidation of allamandin, an anti-leukemic iridoid lactone from Allamanda cathartica, J. Org. Chem., 39, 2477-2482 (1974). 

Approximately 30% of patients with AML exhibit dys-regulation of the FLT3 oncogene, due either to mutation or amplification of internal tandem repeats (ITD) (Lee et al. 2005). Such abnormalities carry a relatively poor prognosis. This has prompted the development of FLT3 inhibitors for such patients (e.g., PKC-412), either as monotherapy, or more commonly, in combination with standard anti-leukemic regimens (Weisberg et al. 2002 Stone et al. 2005 Furukawa et al. 2007). 

Dirsch, V.M., Antlsperger, D.S., Hentze, H., and Vollmar, A.M. 2002. Ajoene, an experimental anti-leukemic drug mechanism of (tell death. Leukemia 7(5(1) 74—83. 

Chakrapani, H., Goodblatt, M.M., Udupi, V., Malaviya, S., Shami, P.J., Keefer, L.K., and Saavedra, J.E. (2008). Synthesis and in vitro anti-leukemic activity of structural analogues of js-k, an anti-cancer lead compound. Bioorg. Med. Chem. Lett. 18, 950-953. 

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