Anti-inflammatory effect mutagenicity

Methyl chloride was mutagenic to bacteria and induced chromosomal aberrations in plants. It induced unscheduled DNA synthesis in cultured rat hepatocytes and, in rats exposed in vivo, there was a small increase in unscheduled DNA synthesis in hepatocytes but not in tracheal epithelial cells or spermatocytes. DNA strand breaks were induced by methyl chloride in the kidney cells of exposed mice. In cultured mammalian cells, it induced mutations and sister chromatid exchanges and enhanced viral cell transformation. It induced dominant lethal effects in rats. The last effect appears to be due to a failure of the males to fertilize the females, rather than to preimplantation embryonic death and can be partially inhibited by treatment with an anti-inflammatory agent (Chellman et al., 1986c). 

Anti-inflammatory, anti-mutagenic, and anti-carcinogenic effects Rosemary Antioxidant effect possibly by scavenging of OH radical, singlet oxygen, and peroxynitrite... 

Hesperetin has a variety of biological effects in numerous mammalian cell systems, in vitro as well as in vivo. They have been shown to exert antimicrobial, antiviral, antiulcerogenic, cytotoxic, antineoplastic, mutagenic, anti-inflammatory, antioxidant, antihepatotoxic, antihipertensive, hypolipidemic and antiplatelet activities. The next topic will discuss the biological potential of hesperetin eombating tropical diseases, anti-tumor, obesity, diabetes and cardiovascular diseases. 

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