Anti-inflammatory effect anxiolytic effects

Citrus aurantium L. -laranja Nervous disturbanees Leaf (Infusion) Afro-Brazilians (Northeast Brazil) [45,46] Alkaloids [195,196] adrenergic amines [197,198] flavonoids [199,200] Coumarins, fatty acids [201,202] polyphenolic compounds [203] essential oils [204,205] Suppressive effect [267] ischemic stroke [268] cardiovascular changes [269] weight loss [267] induction of apoptosis [270] anxiolytic and sedative effects [271] adrenergic agonists [272], antiobesity [273,274] anti-inflammatory activity [275]... 

One fact that is worthy of note relates to Cymbopogon citratus Staf. This is one of the plants most utilized in popular medicine in Brazil many studies have been carried out with this plant. Some studies show that this plant produces evidence of an absence of hypnotic and anxiolytic effects [382], with no effect on nervous and gastrointestinal disorders [383] it is a plant with no toxicity [384]. Anti-inflammatory action was observed [385], in addition to an analgesic effect confirmed by different authors [386-388]. Palmieri [389], however, observed an anxiolytic effect utilizing the essential oils of the plant, while studies by Leite et al. [382] and Carlini et al. [383] which did not verified this effect, utilized hydroalcoholic extract. 

Its pharmacology in vitro and in vivo presents potential remedies in antioxidant, anti-inflammatory, anticancer, antidiabetic, hypertension protection, anti-rheumatoid arthritis, wound healing, brain improvement and neuroprotective effect, gastric ulcer prevention, cardioprotection, anxiolytic activity, and venous hypertension improvement. The clinical study of triterpenoid centellosides has shown its potential in venous hypertension-related improvements. Due to its great prospect and potential, this chapter will present the recent application of triterpenoid centellosides in healthcare covering the pharmacological (in vivo and in vitro) and clinical studies as well as its chemical composition and safety. 

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