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Anti-HIV protein

Zucchini yellow mosaic virus Fusion with CP with protease cleavage anti-HIV proteins 37... [Pg.79]

Momordica charantia L. Ku Gua (Bitter melon) (seed) Anti-HIV protein MAP 30, sterol.33 351 408 423 For immune disorders and common infections. Capable of inhibiting infection of HIV-1 in T. lymphocytes and monocytes, anti-tumor. [Pg.113]

Rajaganapathi, J., Kathiresan, K., and Singh, T. P. (2002). Purification of Anti-HIV Protein from Purple fluid of the sea hare Bursatella leachii de Blainville. Mar. Biotechnol. 4,447-453. [Pg.168]

Sowder II, R.C., Turpin, J., Watson, K., Buckheit Jr, R.W., Boyd, M.R. A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Biochemistry 2003, 42, 2578-2584... [Pg.495]

M. R., Wlodawer, A., Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides, J. Biol. Chem. 277, 34336-34342, 2002. [Pg.1417]

To determine if the high in vitro potents of the anti-HIV compound 30 translates into antiviral efficiency in vivo, Datema et al. investigated the inhibition of HIV-1 production and of depletion of human T cells in HIV-1-infected SCID-hu Thy/Liv mice [37]. Steady levels of 100 ng of 30 or higher per mL in plasma resulted in significant inhibition of HIV p24 protein formation. Daily injection of 30 caused a dose-dependent decrease in viral p24 production, and this inhibition could be potentiated by coadministration of AZT (or DDI). This study suggested that 30 alone or in combination with the licensed anti-HIV agents AZT and DDI may decrease the virus load in HIV-infected patients and, by extension, that the infectious cell entry step is a valid target for antiviral chemotherapy of HIV disease. [Pg.161]

There is potential in the anti-HIV field. Polyoxometallates of the Keggin type bind to viral envelope sites on cell surfaces and interfere with virus adsorption. Metal-chelating macrocyclic bicyclam ligands are among the most potent inhibitors of HIV ever described, and there is considerable interest in the role of Zn proteins in the viral life cycle. [Pg.184]

Ribozymes are a class of metallo-enzymes based on RNA rather than proteins. They have potential in clinical medicine, for example, as potential anti-HIV agents (568, 569) and as possible new tools for the treatment of cancer (570). The active structures of ribozymes contain domains of stacked helices which pack together through tertiary contacts. Divalent metal ions such as Mg(II), Zn(II), and Mn(II) can tune the reactivity and shape the structures of ribozymes (571). Manganese(II) and Mg(II) have similar hexacoordinate ionic radii (0.86 and 0.97 A, respectively) (572) and octahedral geometry ( )Ka of hydrates Ca(II), 12.7 Mg(II), 11.4 Mn(II), 10.7 Zn2+, 9.6) (571). There are several potential oxygen donors on the ribose sugar moiety. [Pg.276]

Patients and blood donors are routinely screened for exposure to HIV by means of ElISA and Western blot assays of blood samples (F uie 1-7-15). The assays are designed to detect antibodies to HIV in the blood of the test subject The ELISA is used as the primary screening assay because it is very sensitive. Because the reference interval for the test is set to include everyone with antibodies to HIV, it also gives false positives and thus has a rather low positive predictive value, especially in low-risk populations. The Western blot (or immunoblot) is used as the confirmatory test for HIV exposure. In the Western blot technique, specific HIV proteins are separated by gel electrophoresis and blotted to a filter. The filter is incubated with the test sample. If the sample contains antibodies to HIV, they will bind to the proteins on the filter. The filter is next washed and incubated with a labeled goat anti-human IgG to visualize any bound human antibodies. The Western blot is highly specific. The combination of an ELISA and Western blot has a positive predictive value of greater than 99%,... [Pg.106]

Betunilic acid (65) Triterpenoid Bevirimat (PA-457) (66) Antiviral (anti-HIV) Inhibits the final step of the HIV Gag protein processing and tiius blocks HIV maturation Phase 11b Panacos Pharmaceuticals 566-573... [Pg.62]

The specific labeled separated protein fractions blotted on a nitrocellulose membrane or specific immunoflxation-separated protein fractions in polyacrylamide after isoelectric focusing make it possible to detect some additional bands in CSF, i.e., IgM, IgA, free kappa or lambda light chains of specific antibodies (i.e., antiherpes, anti-borrelia, or anti-HIV) (LI, M3). [Pg.31]


See other pages where Anti-HIV protein is mentioned: [Pg.83]    [Pg.390]    [Pg.845]    [Pg.1214]    [Pg.105]    [Pg.105]    [Pg.488]    [Pg.489]    [Pg.448]    [Pg.379]    [Pg.83]    [Pg.390]    [Pg.845]    [Pg.1214]    [Pg.105]    [Pg.105]    [Pg.488]    [Pg.489]    [Pg.448]    [Pg.379]    [Pg.206]    [Pg.275]    [Pg.44]    [Pg.194]    [Pg.277]    [Pg.277]    [Pg.116]    [Pg.168]    [Pg.170]    [Pg.171]    [Pg.369]    [Pg.275]    [Pg.276]    [Pg.318]    [Pg.1230]    [Pg.315]    [Pg.13]    [Pg.444]    [Pg.312]    [Pg.314]    [Pg.246]    [Pg.232]    [Pg.143]    [Pg.411]    [Pg.207]    [Pg.272]    [Pg.487]   
See also in sourсe #XX -- [ Pg.105 ]




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Anti-HIV

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