Bursatella leachii

Rajaganapathi, J., Kathiresan, K., and Singh, T. P. (2002). Purification of Anti-HIV Protein from Purple fluid of the sea hare Bursatella leachii de Blainville. Mar. Biotechnol. 4,447-453. 

Appleton DR, Sewell MA, Berridge MV, Copp BR (2002) A New Biologically Active Malyngamide from a New Zealand Collection of the Sea Hare Bursatella leachii. J Nat Prod 65 630... 

Suntomchashwej S, Chaichit N, Isobe M, Suwanborirux K (2005) Hectochlorin and Morpholine Derivatives from the Thai Sea Hare, Bursatella leachii. J Nat Prod 68 951... 

The structure of bursatellin, a metabolite from the Puerto Rican sea hare Bursatella leachii pleii (389), was revised to be 483, possessing an N-formyl amide functionality, by detailed spectroscopic analysis using the compound (483) isolated from the Mediterranean B. leachii leachii and B. leachii savignyana (390). The optical rotation of bursatellin (483) from the Mediterranean sample, however, was of opposite sign to that reported... 

D.B. Carlini, J.D. Regan (1995). Photolyase activities of Elysa tuca, Bursatella leachii, and Haminaea antillarum (Mollusca Opisthobranchia). J. Exp. Mar. Biol. Ecol, 189, 219-232. 

The extracts of Bursatella leachii pleii consisted mainly of aliphatic lipids, but among the minor components Gopichand and Schmitz 560) had isolated a novel dinitrile, bursatellin (870). 

Gopichand, Y., and F.J. Schmitz Bursatellin A New Diol Dinitrile from the Sea Hare Bursatella leachii pleii. J. Org. Chem. 45, 5383 (1980). 

Cyclopropanic fatty adds are rarely encormtered in mollusks, though the sea hare Bursatella leachii (an opis-thobranch) harvested in the Gulf of Mexico, Texas, has yielded an unusual acid with 20 carbon atoms, which represents 75% of the total add fradion. 

Suenaga et a1996a, Bursatellin is probably the first non-peptidic nitrogenous derivative isolated from a sea hare. Discovered in 1980 in Bursatella leachiipleii collected in Puerto Rico, this dinitrile diol was re-isolated in 1987 from the Mediterranean anaspids Bursatella leachii kachii and B. 1. savignyana and its revised structure was confirmed by synthesis... 

Comprising two thiazole nuclei like dolabellin, hecto-chlorin and deacetylhectochlorin are macrolactones isolated from the Thai sea hare Bursatella leachii. The deacetylated form is strongly cytotoxic to several human cancerous lines, unlike hectochlorin (Suntomchashwej et al., 2005). 

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