Anti-cancer marine natural products

Figure 11 Antiinflammatory or anti-cancer marine natural products and synthetic analogs that are in commercial use or in clinical and preclinical evaluation...

Mickel, S.J., Sedelmeier, G.H., Niederer, D. etal. (2004) Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (-P)-Disco derm olide. Part 1 Synthetic Strategy and Preparation of a Common Precursor. Organic Process Research Development, 8, 92-100. 

ER, Konigsberger K, Prasad K, Ramsey TM, Repic O, Wang R-M, Elorence G, Lyothier I, Paterson I. Large-scale synthesis 120. of the anti-cancer marine natural product + -discodermolide. Part 5 linkage of fragments C and Finale. Org. Process Res. Dev. 2004 8 122-130. 121. 

Loeser, E., Kinder, F. R., Konigsberger, K., Prasad, K Ramsey,T. M., Repic, O., Wang, R. M., Florence, G., Lyothier, L, Paterson, L, Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (-t)-Discodermolide. Part 5 Linkage of Fragments Cl-6 and C7-24 and Finale, Org. Proc. Res. Dev. 2004, 8, 122-130. 

Mickel SJ, Sedelmeier GH, Niederer D, Schuerch F, Grimier D, Koch G, Daeffler R, Osmani A, Hirni A, Schaer K, Gamboni R. Large-scale synthesis of the anti-cancer marine natural product (+)-Discodermolide. Part 2 synthesis of fragments Ci g and C9 i4. Org. Process Res. Dev. 2004 8 101-106. 

The majority of promising drug candidates emerging from marine natural products research to date are potential cancer treatments. Six anti-cancer compounds that are either marine natural products or synthetic analogs of marine natural products have made it to clinical trials. The first of these compounds to enter clinical trials was didemnin B (43), one of a family of cyclic depsipetides isolated from the Caribbean tunicate Trididemnum solidum Didemnin B was advanced to Phase II clinical trials for treatment of small cell lung cancer, myeloma, prostate cancer, and melanoma. Unfortunately, no favorable responses were found so the compound has been withdrawn. Crude extracts of another Caribbean tunicate, Ecteinascidia turbinata, showed extremely... 

Figure 3.3. Bryostatin 2. Bryostatin 2 (C HggOjg) is a biologically active marine natural product which may have useful anti-cancer properties. It was recently synthesised at Harvard by Professor David Evans and his research group. In this illustration, all of the hydrogen atoms are omitted in order to simplify the structure. The lower diagram shows a low energy conformation of bryostatin 2, but it may only be a local minimum and not a global minimum. Many other conformations are accessible at room temperature.

Barrows LR, Radisky DC, Copp BR, Swaffar DS, Kramer RA, Warters RL, Ireland CM (1993) Makaluvamines, Marine Natural Products, are Active Anti-Cancer Agents and DNA Topo II Inhibitors. Anti-Cancer Drug Design 8 333... 

C. M., Makaluvamines, marine natural products, are active anti-cancer agents and DNA topoisomerase II inhibitors, Anti-Cancer Drug Design, 8, 333, 1993. 

Current Medicinal Chemistry-Anti- Cancer Agents Since 2001, this journal has been renamed Anticancer Agents in Medicinal Chemistry. Among developments devoted to marine natural products it is worth mentioning ... 

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