Anti-AIDS agents

Fujioka T, Kashiwada Y, Kilkuskie RE, Cosentino EM, Balias LM, Jiang JB, Janzen WP, Chen IS, Lee K-H. (1994) Anti-AIDS agents, 11. betulinic acid and platanic acid as anti-HIV principles from syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. J Nat Prod 57 243-247. 

Hashimotof E, Kashiwadaf Y, Cosentino LM, Chen C-H, Garrett PE, Lee K-H. (1997) Anti-AIDS agents XXVll Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. Bioorg Med Chem 5 2133-2143. 

Wu, J.-H. et al., Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from the genus Desmos, Bioorg. Med. Chem. Lett., 13, 1813, 2003. 

Anti-AIDS Agents — Novel Plant Anti-HIV Compounds and Analogs... 

The sesquiterpene quinones and hydroquinones display a wide range of biological activities.4 Some of the compounds are cytu-toxic, whereas others show antimicrobial characteristics. Avarol (2) has been the subject of investigation as a consequence of its ability to inhibit reverse transcriptase, but no clinical value (as an anti-AIDS agent, for example) has yet been established.3... 

Three enzymes with anti-HIV activity have been identified in the urine of women in the early months of pregnancy.9 Lee-Huang and her colleagues have now traced the anti-HIV activity to two ribonucleases and a lysozyme. The ribonucleases can digest RNA from a variety of sources, including cells infected with HIV-1. These proteins offer promise as anti-AIDS agents. The exact mechanism as to how these enzymes work needs to be worked out. 

This investigation entitled Anti-AIDS Agents 63 was supported by Grant AI-33066 from the National Institute of Allergies and Infectious Diseases awarded to K. H. Lee. We wish to express our sincerest thanks to Dr. Susan L. Morris-Natschke for her experienced editing. Also, we acknowledge the contributions from our collaborators, most of whom are cited in the references. ... 

K. H. Anti-AIDS agents 17. New brominated hexahydroxybiphenyl derivatives as potent anti-HIV agents. J. Med. Chem., 1995, 38 3003-3008. 

Lee, K. H. Kashiwada, Y Nonaka, G. Nishioka, I. Nishizawa, M. Yamagishi, T. Bodner, A. J. Kilkuskie, R. E. Cheng, Y. C. Anti-AIDS agents 7. Tannins and related compounds as anti-HIV agents. In Chu, C. K. Cutler, H. G. editors. Natural Products as Antiviral Agents. New York Amer. Chem. Soc. Symposium Series, Plenum Press, 1992, 69-90. 

Huang L, Kashiwada Y, Cosentino LM, Fan S, Chen CH, McPhail AT, Fujioka T, Mihashi K, Lee KH. Anti-AIDS agents 15. Synthesis and anti-HIV activity of dihydrosesehns and related analogs. J. Med. Chem. 1994 37 3947-3955. 

Yu D, Wild CT, Martin DE, Morris-Natschke SL, Chen CH, Allaway G, Lee KH. Anti-AIDS agents 64. The discovery of... 

Yu D, Lee KH. Anti-AIDS agents 63. Recent progress and prospects on plant-derived anti-HIV agents and analogs. In Medicinal Chemistry of Bioactive Natural Products. Liang XT, Fang WS, eds. 2006. John Wiley Sons, Hoboken, NJ, pp. 357-398. 

Yu D, Morris-Natschke SL, Lee KH. Anti-AIDS agents 67. New developments in natural products-based anti-AIDS research. Med. Res. Rev. 2007 27 133-148. 

Additionally, as nucleosides and nucleotides they act as hormones and nenrotransmitters and are present in some co-enzymes. The interconversion of mono-, di- and triphosphate esters of nncleosides is at the heart of energy transfer in many metabolic systems and is also involved in intraceUnlar signalling. This central biological importance, together with medicinal chemists search for anti-tnmonr and anti-viral (particularly anti-AIDS) agents, have resulted in a rapid expansion of purine chemistry (33.6.3). 

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