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Antagonists, from natural sources

Antagonists from Natural Sources. Merck performed a screen ( I-CXCLIO) on a library consisting of extracts from microbial, plant and marine sources [86]. A diverse series of hits was found, including sugar-derivatized steroids and dipyridinium salts. [Pg.310]

Daly JW (2005) Nicotinic agonists, antagonists, and modulators from natural sources. Cell Mol Neurobiol 25 513-552... [Pg.1363]

The thalidomide tragedy, described in chapter 7, started to focus the pharmaceutical industry on synthesis of single enantiomers rather than racemic mixtures. Even if there are no antagonistic or undesirable side effects from the other enantiomer, a racemic mixture may waste 50 percent of the mass of a drug. Optically pure compounds such as vitamin B]2, morphine, and L-dopa are available naturally. In some cases (e.g., vitamin B12), the natural source is really the only practical source. For simpler compounds like L-dopa, chemical synthesis is very practical but resolution of enantiomers may double the production cost. [Pg.281]

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See also in sourсe #XX -- [ Pg.310 ]



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Antagonists natural

Natural sources

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