Annual reports of medicinal chemistry

Sources Textbooks of Medicinal Chemistry, Annual Reports of Medicinal Chemistry. 

Bisphosphonates that have been approved for clinical use, as reported in the Annual Report of Medicinal Chemistry, are listed in Tab. 15.1. It should be noted that although a BP may have gained initial approval for a specific clinical indication, its subsequent use in various countries may not be necessarily limited to that indication. 

Magnesium pemoline was briefly alluded to in the 1965 "Annual Reports of Medicinal Chemistry" (page 23) as promoting the biosynthesis of RNA in rat brain and facilitating learning by increasing memory and retention of learned behavior. Subsequent reports have made these findings controversial and... 

Clark DE (2005) Computational prediction of blood-brain barrier permeation. In Doherty A (ed) Annual reports in medicinal chemistry. Elsevier, Oxford, p 413... 

In summary, I hope that Volume 45 of Annual Reports in Medicinal Chemistry continues to be a key reference for your medicinal chemistry pursuits. As Editor-in-Chief, I continue to look for ways to optimize, improve, and evolve the series. Please do not hesitate to contact me with suggestions for improving the series [john.macor bms.com]. Thank you. 

Wermuth, C.G., Ganellin, C.R., Lindberg, P. and Mitcher, L.A. (1998) Glossary of terms used in medicinal chemistry (UPAC Recommendations 1997). Annual Reports in Medicinal Chemistry, 33, 385-395. 

Hencken CP, Kalinda AS, D Angelo JG. (2009) The anti-infective and anti-cancer properties of artemisinin and its derivatives in JE Macor (ed.). Annual Reports In Medicinal Chemistry, Vol 44 Academic Press, pp. 359-378. 

Obach, R.S. (2007) Prediction of human volume of distribution using in vitro, in vivo and in silico approaches. Annual Reports in Medicinal Chemistry, 42, 469-488. 

Bender PE, Lee JC., eds. Pharmacological modulation of interleukin-1 (1989). Annual reports in medicinal Chemistry-25. Johns. Section IV-Metabolic diseases and endocrine function. Chapter 20. 

Clark, A.R., et al. (2006) The application of pulmonary inhalation technology to dmg discovery. Annual Reports in Medicinal Chemistry, 41 p. 384-393. 

Chen X, Wang W. The use of bioiso-steric groups in lead optimization. Annual Reports in Medicinal Chemistry. Elsevier, Amsterdam, 2003. 

This chapter has limited the discussion to only certain examples of chemoge-nomics in drug discovery, though further examples and systematic reviews are available in Ref. 4 and in recent volumes of the Annual Reports in Medicinal Chemistry. Nevertheless, these examples show the great potential of searching for new... 

G. Nemeth and D. Kassel, Existing and emerging strategies for the analytical characterization and profiling of compound libraries, in G. Trainor (ed.), Annual Reports in Medicinal Chemistry, Academic Press, 2001, pp. 277-292. 

M Suffhess, "Taxol From Discovery to Therapeutic Use" in J. A Bristol, Ed., Annual Report (f Medicinal Chemistry, Vol. 28, Academic Press, New York, 1993, pp. 305-314, provides a good review of the discovery and development of taxol and related derivatives. 

The Editors of Annual Reports in Medicinal Chemistry continue to welcome comments from its readers. We are especially interested in suggestions for new topics which will make future volumes more useful. 

SD Nelson, LR Pohl. The use of stable isotopes in medicinal chemistry. In Annual Reports in Medicinal Chemistry. Vol. 12. New York Academic Press, 1977, pp 319-329. 

Introduction - The search for new antihypertensives and for a better understanding of existing ones remains quite intense with emphasis this past year on 3-blockers (see Chapter 9) and on agents that affect the renin-angiotensin system. Diuretics were reviewed last year and are not included in this chapter. Structures of drugs mentioned in this review are shown or may be found in recent volumes of Annual Reports in Medicinal Chemistry. 

Weber AE, Thomberry N. Case history JANUVIA (sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Annual Reports in Medicinal Chemistry 42, 95, 2007. 

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