Magnesium pemoline

More research has been done on pharmacotherapy of ADHD in children and adolescents with MR than for other disorders. Reviews by Aman (1996), Arnold et al. (1998), and Handen (1993) summarize the psychostimulant research (methylphenidate, amphetamine, and magnesium pemoline). Of the 10 or more group studies of methylphenidate or dextroamphetamine in children, adolescents, and adults with ADHD and MR/ DD since 1980, all but one were positive and statistically significant. They showed substantial benefit for motor overflow, attention span, and impulsiveness. Improvements were also seen in cognitive performance, some measures of social behavior, and independent play. The sole negative study was of adolescents and adults without ADHD, most of them with profound MR (see Aman, 1996). No studies of mixed amphetamine salts (Adderall) or magnesium pemoline (Cylert) were found for this population (Arnold et al., 1998). 

Orzack MH, Taylor CL, Kometsky C. A research report on the anti-fatigue effects of magnesium pemoline. Psychopharmacology 1968 13 413-417. 

Gelfand S, Clark LD, Herbert EW, Gelfand DM, Holmes ED. Magnesium pemoline Stimulant effects on performance of fatigued subjects. Clin Pharmacol Ther 1968 9(l) 56-60. 

Magnesium pemoline was briefly alluded to in the 1965 "Annual Reports of Medicinal Chemistry" (page 23) as promoting the biosynthesis of RNA in rat brain and facilitating learning by increasing memory and retention of learned behavior. Subsequent reports have made these findings controversial and... 

Magnesium hydroxide mixture, magnesium pemoline, dbbott 30400, Ecylert, Tamitan. 

Methylphenidate (15) and magnesium pemoline (16) were more effective than placebo in mildly depressed outpatients however, psychiatric patients did not respond well to these stimulants.In a study dealing with a group of "neurophysiologic immature" inpatient children, minimal doses of methylphenidate produced favorable improvement in five of eight children.S3... 

Magnesium pemoline some doses were given 2 weeks pre-irradiation. Phenylhydrazine hydrochloride (CgH NHNH- HCl) when administered 5-8 days before Irradiation stimulation of erythropolesls and an Increase In stem cells may explain the protective effect. 

The question of the possible facilitation of learning by central stimulants is complex and little new material can be added to last year s excellent review. Recent work indicates that neither caffeine nor magnesium pemoline enhances learning rate. 

If magnesium pemoline has a generalized acquisition-enhancing effect in rats. Independent of its stimulant effect, one might also expect it to facilitate acquisition under conditions where response restraint indicates appropriate b avlor, as well as in "rapid response" situations. But only negative results have been reported ... 

Tricyanoaminopropene (TCAP U-9189) - Like magnesium pemoline, TCAP attained prominence as a potential learning-enhancing compound following a reported effect on neural RNA. It had initially been reported that the common intermediate, malononltrlle, stimulates nucleic acid production in... 

PEMOLINE MAGNESIUM -- [2-imino-5-phenyl-4-oxazolidinonato(2)-] diaquomagnesium. 

Material A complex from equimolar mixture of pemoline and magnesium hydroxide under study in Abbott Laboratories as an adjunct to learning and memory. 

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