Pulmonary inhalation technology

Clark, A.R., et al. (2006) The application of pulmonary inhalation technology to dmg discovery. Annual Reports in Medicinal Chemistry, 41 p. 384-393. 

Clark A. Pulmonary delivery technology recent advances and potential for the new millennium. In Hickey AJ, ed. Pharmaceutical Inhalation Aerosol Technology. 2d ed. New York Marcel Dekker, 2004. 

Humberstone, V.C. Sant, A.J. van Rensburg, R.J. Piezoelectric Aerosol Inhalers Technology to Product, Conference Proceedings of New Horizons in Pulmonary Drug Delivery, October, 1-2, 1996. 

In 1999, the Pulmonary Division of FDA issued draft guidelines for MDIs, DPIs and nebuliser systems (FDA 1998) which reflect their current thinking, and are now undergoing a review process with the Inhalation Technology Focus Group of the American Association of Pharmaceutical Scientists (AAPS) and industry groups. The CPMP stated its intention to issue... 

The first MDI products were developed by Riker Laboratories and marketed in 1956, using a newly patented design of metering valve. In most countries the MDI is now established as the principal dosage form of inhalation drug therapy for bronchial asthma and chronic obstructive pulmonary disease (COPD). Since its introduction, MDI technology has evolved steadily. However, with the phase-out in the commercial use of chlorofluorocarbon (CFC) propellants, which have been the mainstay of pharmaceutical MDIs, the pace of MDI technology development has accelerated with the transition to hydrofluorocarbon (HFC) propellants. ... 

Figure 2 Pulmonary technology patent filings per year related to either metered-dose or dry powder inhalers. (Data generated using Aurigin Inc. patent search engine. Numbers may be slight overestimates of total related patents, due to restriction in search terms.)...

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