Animal models regulation

Tran PB, Ren D, Veldhouse TJ, Miller RJ (2004) Chemokine receptors are expressed widely by embryonic and adult neural progenitor cells. J Neurosci Res 76 20-34 Tran PB, Banisadr G, Ren D, Chenn A, Miller RJ (2007) Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain. J Comp Neurol 500 1007-1033 U eyler N, Sommer C (2008) Cytokine regulation in animal models of neuropathic pain and in human diseases. Neurosci Lett 437 194-198... 

Keywords Alternatives to animal testing, Computational toxicology, In silico, In vitro, Predictive models, QSAR models, Regulation... 

An impressive number of proteins that are involved in iron transport have been identified in recent years (Andrews, 1999 Griffiths et al., 1999). Most of them can either be up-regulated or down-regulated in situations of iron deficiency and different forms of iron overload, in order to maintain a safe iron balance. However, variations in the absolute levels or genetic defects of these proteins may cause iron overload or iron deficiency. In many forms of iron-related pathology detailed information can be obtained using appropriate animal models. 

During the last decade, the development of animal models with selective ablation of specific genes has allowed the identification of physiological responses associated with each receptor subtype, as well as their complementarity in the regulation of reproductive function (Lubahn et al. 1993 Krege et al. 1998 Dupont et al. 2000). In addition, a large number of recent reports have shown that in a variety of tissue and cell types sex steroids are also able to interact with... 

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