Angiotensin-converting enzyme polymorphisms

Monastero, R., CalsareUa, R., Mannino, M., et al. (2002) Lack of association between angiotensin converting enzyme polymorphism and sporadic Alzheimer s disease. Neurosci. Lett., 335, 147-149. 

Keavney B, McKenzie C, Parish S, Palmer A, Clark S, Youngman L et al. Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators. Lancet 2000 355 434—442. 

Schunkert H. Polymorphism of the angiotensin-converting enzyme gene and cardiovascular disease. J Mol Med 1997 75 867-875. 

Buikema H, Pinto YM, Rooks G, Grandjean JG, Schunkert H, van Gilst WH. The deletion polymorphism of the angiotensin-converting enzyme gene is related to phenotypic differences... 

Duru K, Farrow S, Wang J-M, Lock-ette W, Kurz T. Frequency of a deletion polymorphism in the gene for angiotensin converting enzyme is increased in African-Americans with hypertension. 

Murphey LJ, Gainer JV, Vaughan DE, Brown NJ. Angiotensin-converting enzyme insertion/deletion polymorphism modulates the human in vivo metabolism of bradykinin. Circulation. 2000 102 829-832. 

Prasad A, Narayanan S, Waclawiw MA, Epstein N, Quyyumi AA. The insertion/deletion polymorphism of the angiotensin-converting enzyme gene determines coronary vascular tone and nitric oxide activity. J Am Coll Cardiol 2000 36 1579-1586. 

Butler R, Morris AD, Burchell B, Struthers AD. DD angiotensin-converting enzyme gene polymorphism is associated with endothelial dysfunction in normal humans. Hypertension 1999 33 1164-1168. 

Perticone F, Ceravolo R, Maio R, Ventura G, Zingone A, Perrotti N, Mat-tioli PL. Angiotensin-converting enzyme gene polymorphism is associated with endothelium-dependent vasodilation in never treated hypertensive patients. Hypertension 1998 31 900-905. 

Hingorani AD, Stevens PA, Hopper R, Dickerson JEC, Brown MJ. Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition. J Hypertens 1995 13[pt. II] 1602—1609. 

Tiret, L., Bonnardeaux, A., Poirier, O., et al. (1994) Synergistic effects of angiotensin-converting enzyme and angiotensin-11 type-1 receptor gene polymorphisms on risk of myocardial-infarction. Lancet. 344, 910-913. 

Tomino, Y., Makita, Y., Shike, T., et al. (1999) Relationship between polymorphism in the angiotensinogen, angiotensin-converting enzyme or angiotensin 11 receptor and renal progression in Japanese NIDDM patients. Nephron. 82, 139-144. 

Alvarez, R., Alvarez, V., Lahoz, C.H., et al. (1999) Angiotensin converting enzyme and endothelial nitric oxide synthase DNA polymorphisms and late onset Alzheimer s disease. J. Neurol Neurosurg. Psychiatry, 67, 733-736. 

De Olano, M., Fernandez-Novoa, L., Mesa, M.D., Corzo, L., Cacabelos, R. (2000) Different allelic frequency distribution in angiotensin-converting enzyme I/D polymorphism and angi-otensinogen M235T polymorphism in dementia. In Sixth International Stockholm/ Springfield Symposium Advanced Alzheimer Therapy, Stockholm, p. 202. 

Cheng, C.Y., Hong, C.J., Liu, H.C., Liu, T.Y., Tsai, S.J. (2002) Study of the association between Alzheimer s disease and angiotensin-converting enzyme gene polymorphism using DNA from lymphocytes. Eur. Neurol., 47, 26-29. 

Purandare, N., Oude Voshaar, R.C., Davidson, Y., et al. (2006) Deletion/insertion polymorphism of the angiotensin-converting enzyme gene and white matter hyperintensities in dementia a pilot study. J. Am. Geriatr. Soc., 54, 1395-1400. 

Wang, H.K., Fung, H.C., Hsu, W.C., et al. (2006) Apolipoprotein E, angiotensin-converting enzyme and kaUikrein gene polymorphisms and the risk of Alzheimer s disease and vascular dementia. J. Neural Transm., 113, 1499-1509. 

Some patients seem to have an inherent genetic susceptibility to restenosis following coronary stent implantation. Research has shown that patients homozygous for the deletion D) allele of angiotensin converting enzyme ACE) gene polymorphism lack functional enzyme and are at increased risk. These patients have ele-... 

L2. Lee, D. Y., Kim, W., and Kang, S. K., Angiotensin-converting enzyme gene polymorphism in patients with minimal-change nephrotic syndrome and focal segmental glomerulosclerosis. Nephron 77,471-473 (1997). 

Human PepTl was initially cloned from intestine (92) and was found to be localized to the brush border of intestinal epithelial cells (93) and in SI segment of apical proximal tubules (94). PepTl transports (3-lactam antibiotics (95), antiviral drugs such as valacyclovir and valganciclovir (96), and the angiotensin converting enzyme inhibitor captopril (97). Polymorphisms have been reported, however little is known regarding their functional consequences (64). 

Rankinen, T., L. Perusse, J. Gagnon, Y.C. Chagnon, A.S. Leon, J.S. Skinner, J.H. Wilmore, D.C. Rao, and C. Bouchard (2000). Angiotensin-converting enzyme ID polymorphism and fitness phenotype. HERITAGE Fam. Study J. Appl. Physiol. 88 1029-1035. 

Mukae S, Aoki S, Itoh S, Iwata T, Ueda H, Katagiri T. Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough. Hypertension 2000 36(1) 127-31. 

McNamara DM, Holubkov R, Postava L et al (2004) Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure. J Am Coll Cardiol 44 2019-2026... 

O Toole L, Stewart M, Padfield P et al (1998) Effect of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene on response to angiotensin-converting enzyme inhibitors in patients with heart failure. J Cardiovasc Pharmacol 32 988-994... 

Stavroulakis GA, Makris TK, Krespi PG, et al. Predicting response to chronic antihypertensive treatment with fosinopril The role of angiotensin-converting enzyme gene polymorphism. Cardiovasc Drugs Ther 2000 14 427-432. 

Kohno M, Yokokawa K, Minami M, et al. Association between angiotensin-converting enzyme gene polymorphisms and regression of left ventricular hypertrophy in patients treated with angiotensinconverting enzyme inhibitors. Am J Med 1999 106 544-549. 

Jacobsen P, Rossing K, Rossing P, et al. Angiotensin-converting enzyme gene polymorphism and ACE inhibition in diabetic nephropathy. Kidney Int 1998 53 1002-1006. 

Evans, A. E., et al., Polymorphisms of the angiotensin-converting-enzyme gene in subjects who die from coronary heart disease. QJ Med, 1994. 87(4) p. 211-4. 

Schunkert, H., et al., Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy [see comments]. N Engl J Med, 1994. 330(23) p. 1634-8. 

Montgomery, H., et al., Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training [see comments]. Lancet, 1999. 353(9152) p. 541-... 

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