Heart failure angiotensin-converting enzyme

Angiotensin converting enzyme (ACE) plays a central role in cardiovascular hemostasis. Its major function is the generation of angiotensin (ANG) II from ANGI and the degradation of bradykinin. Both peptides have profound impact on the cardiovascular system and beyond. ACE inhibitors are used to decrease blood pressure in hypertensive patients, to improve cardiac function, and to reduce work load of the heart in patients with cardiac failure. [Pg.9]

Chymostatin-sensitive Il-generating enzyme Carvedilol Post-Infarct Survival Control in Left Ventricular Dysfunction Trial Collaborative Study Captopril Trial ( The Effect of Angiotensin-Converting Enzyme Inhibition on Diabetic Nephropathy ) calcium channel blocking agents Candesartan in Heart Failure Assessment of Reduction in Morbidity and Mortality Trial congestive heart failure, but the latest recommendations use HF for heart failure chronic kidney disease cardiac output... [Pg.31]

FIGURE 3-1. Treatment algorithm for chronic heart failure. ACE, angiotensin-converting enzyme ARB, angiotensin receptor blocker EF, ejection fraction HF, heart failure LV, left ventricular Ml, myocardial infarction SOB shortness of breath. Table 3-5 describes staging of heart failure. [Pg.52]

Medications can increase the risk of hyperkalemia in patients with CKD, including angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, used for the treatment of proteinuria and hypertension. Potassium-sparing diuretics, used for the treatment of edema and chronic heart failure, can also exacerbate the development of hyperkalemia, and should be used with caution in patients with stage 3 CKD or higher. [Pg.381]

Petrie MC, Padmanaban N, McDonald JE, Hillier C, Connell JMC, McMur-ray J J V. Angiotensin converting enzyme (ACE) and non-ACE dependent angiotensin II generation in resistance arteres from patients with heart failure and coronary heart disease. J Am Coll Cardiol 2001 37 1056-1061. [Pg.263]

Angiotensin converting enzymes- inhibitors (ACE-inhibitors) are a group of drugs that are very potent in dilating the blood vessels and through this mechanism lower the blood pressure. Therefore they can also improve heart function in patients with heart failure. In some cases they are also used for preventing renal failure in persons with hypertension and/or diabetes. Paradoxically, this later use of ACE-inhibitors... [Pg.62]

Angiotensin-converting enzyme inhibitors are indicated for use in hypertension and heart failure. Angiotensin-converting enzyme inhibitors have no use in the management of arrhythmias. [Pg.210]

Gattis WA, Larsen RL, Hasselblad V, Bart BA, O Connor CM. Is optimal angiotensin-converting enzyme inhibitor dosing neglected in elderly patients with heart failure . Am Heart J 1998 136(l) 43-8. [Pg.222]

Enalapril maleate is an orally active angiotensin converting enzyme (ACE) inhibitor, it lowers peripheral vascular resistance without causing an increase in heart rate. The maleate salt (enalapril) allows better absorption after oral administration. It is an ideal drug for hypertensive patients who are intolerant to beta-blocker therapy. It also shows promise in the treatment of congestive heart failure. Following oral adminishation, enalapril is rapidly absorbed and hydrolysed to... [Pg.180]

Captopril, many others Inhibit angiotensin converting enzyme Reduce angiotensin II levels reduce vasoconstriction and aldosterone secretion increase bradykinin Hypertension heart failure, diabetes Oral Toxicity Cough, angioedema teratogenic... [Pg.243]

Only the Angiotensin-converting enzyme CACE) inhibitors currently approved for treating heart failure are listed here. See Chapter 21, Table 21 -5 for a more complete list of ACE inhibitors. [Pg.336]

Drug Class Angiotensin-converting enzyme [ACE] inhibitors Suffix -pril Common Examples Captopril, enalapril Primary Indication or Desired Effect (Chapter in Parentheses) Antihypertensive [21], congestive heart failure [24]... [Pg.657]

In addition, a vasodilator in combination with an angiotensin-converting enzyme inhibitor has been used in congestive heart failure. The vasodilators may be classified as venodilators, arterial dilators, or balanced-type vasodilators. [Pg.364]

Parenteral 40, 80, 160 mg/mL for IV injection 80, 160, 320 mg/dL in 5% dextrose for IV infusion Angiotensin-Converting Enzyme Inhibitors Labeled for Use in Congestive Heart Failure Captopril (generic, Capoten)... [Pg.307]

Abbreviations ACE, angiotensin-converting enzyme AMI, acute myocardial infarction EPHESUS, eplerenone postacute myocardial infarction heart failure efficacy and survival study HF, heart failure LVEF, left ventricular ejection fraction NYHA. New York Heart Association RALES, randomized aldactone evaluation study. [Pg.455]

Jorde UP Vittorio T Katz SD, Colombo PC, Latif F Le Jemtel TH, Elevated plasma aldosterone levels despite complete inhibition of the vascular angiotensin-converting enzyme in chronic heart failure, Circulation 2002 106 1055-1057,... [Pg.462]

Granger CB, McMurray JJ, Yusuf S, et al, Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors the CHARM-Alternative trial, Lancet 2003 362 ... [Pg.462]

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