Angiogenic agents

Synthesis and characterization of a new class of anti-angiogenic agents based on ruthenium clusters... 

Nowak-Sliwinska, P., Ballini, J. P., Wagnieres, G. 8c van den Bergh, H. Processing of fluorescence angiograms for the quantification of vascular effects induced by anti-angiogenic agents in the CAM model. Microvasc. Res. 79, 21-28 (2010). 

How to cite this article Nazarov, A. A. et al. Synthesis and characterization of a new class of anti-angiogenic agents based on ruthenium clusters. Sci. Rep. 3, 1485 DOL10.1038/ srep01485 (2013). 

Sin N, Meng L, Wang MQW, Wen JJ, Bommann WG Crews CM. (1997) The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proc Natl Acad Sci USA 94 6099-6103. 

Nusgens, B.V and Castronovo, V. (2002) Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene, 21, 427-436. 

Teicher BA, Holden SA, AraG, et al. Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents. Int J Cancer 1994 57 920-925. 

Kwon, H. J. (2003). Chemical genomics-based target identification and validation of anti-angiogenic agents. Current Medicinal Chemistry 10, 717-736. 

There are a variety of reasons as to why some of these trials failed to show improvement with treatment. Patients selected for these trials are possibly the ones most likely to fail to respond to therapeutic angiogenic agents. They have had multiple percutaneous and surgical revascularization attempts... 

Isaacs JT, et al. (2006) Identification of ABR-215050 as lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of prostate cancer. Prostate 66(16) 1768-1778... 

The vast majority of work done to examine FGF-2 as a cardioprotective or angiogenic agent has focused on lo-FGF-2 acting at the cell surface. As more information is collected with respect to the specific actions of hi-FGF-2, as well as the mitogenic consequences of nuclear signaling, the relative importance of hi vs. lo-FGF-2 and cell surface vs. nuclear signaling in the context of cardioprotection will come to light. For now, we will focus on what is known about the acute and chronic effects of lo-FGF-2 in... 

Grant MB, Mames RN, Fitzgerald C, Ellis EA, Caballero S, etal. 1993. Insulin-like growth fector I as an angiogenic agent. In vivo and in vitro studies. Ann NY Acad Sci 692 230-242. 

Loweher, W. T., McMillen, D. A., Orville, A. M., Matthews, B. W. (1998). The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia call methionine aminopeptidase. Proc. Nat. Acad. ScL USA, 95, 12153-12157. 

Auricchio A, Behling K, O Connor E, et al. Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents. Mol Ther 2002 6 490-494. 

Based on the results described above, Eyetech received Food and Drug Administration approval to market pegaptanib sodium for treatment of patients with neovascu-lar AMD. This drug is the first anti-angiogenic agent to receive approval to treat AMD. 

MDM2 Inhibitors as Potential Anti-angiogenic Agents. 72... 

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