Aneurine monophosphate

Thiamine monophosphate chloride 2H2O (Aneurine monophosphate chloride) [532 -1] M... 

As shown in Figure 6.1, thiamin consists of pyrimidine and thiazole rings, linked by a methylene bridge the alcohol group of the side chain can be esterified with one, two, or three phosphates, yielding thiamin monophosphate, thiamin diphosphate (also known as thiamin pyrophosphate, the metabolically active coenzyme), and thiamin triphosphate. The vitamin was originally named aneurine, the antineuritic vitamin, because of its function in preventing or... 

Vitamin Bj Vitamin Bj was discovered in 1926 by Jansen and Do-NATH, who synthesized it in its crystalline form from rice bran. It was initially called aneurine due to its antipolyneuropathic effect. Because it contains sulphur, Windaus correctly renamed it thiamine in 1932, a term by which it is still known today. The stixicture of this vitamin was described by Williams and Grewe in 1936. It is made up of pyrimidine and thiazole. Thiamine occurs in nature as free thiamine and in the form of thiamine monophosphate, diphosphate and triphosphate. A maximum amount of 8 — 15 mg is absorbed daily in the proximal portion of the small intestine. In the case of oversupply, thiamine is neither stored nor intestinally absorbed. A regular intake, with a daily requirement of about 1 mg, is necessary. The major coenzyme is thiamine pyrophosphate (TPP). Thiamine deficiency may be caused by malnutrition, impaired absorption, alcoholism, antithiamines or a lack of magnesium. Magnesium is an important cofactor for the coenzyme thiamine pyrophosphate. 

This vitamin, also called aneurin, is the antiberiberi factor. The active coenzyme form is thiamine pyrophosphate (TPP), or coearboxylase. Thiamine triphosphate (TTP) may be an active form in the central nervous system. Of the thiamine in the body, 10% occurs as TTP, 80% as TPP, and 10% as TMP (thiamine monophosphate) (Figure 38-12). 

Description. Thiamin is a water-soluble B-complex vitamin, previously known as vitamin B, or aneurine. " Isolated and characterized in the 1930s, thiamin was one of the first organic compounds to be recognized as a vitamin. " Thiamin occurs in the human body as free thiamin and its phosphorylated forms thiamin monophosphate (TMP), thiamin triphosphate (TTP), and thiamin pyrophosphate (TPP). 

Thiamine (vitamin Bj, also formerly known as aneurine) contains a pyrimidine ring (4-amino-2-methylpyrimidine) attached by the methylene group at C-5 to the nitrogen of 5-(2-hydroxyethyl)-4-methylthiazole. Thiamine (5-51) occurs primarily as a free compound and in the form of phosphate esters (5-52), the monophosphate, diphosphate (pyrophosphate called cocarboxylase) and triphosphate. 

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