Anemia specific agents

Inorganic or metal-containing medicinal compounds may contain either (a) chemical elements essential to life forms—iron salts used in the treatment of anemia—or (b) nonessential/toxic elements that carry out specific medicinal purposes—platinum-containing compounds as antitumor agents or technetium... 

Fanconi anemia (FA) is a rare genetic disease. Patients are highly predisposed to developing a wide variety of different types of cancer. Cells from FA patients are specifically hypersensitive to crosslinking agents. These observations lead to the prediction that FA cells are deficient in the repair of ICLs. While evidence for this... 

Some ADRs are caused by most or all medications in a class, while others are agent specific. Nausea, vomiting, and diarrhea have been observed with most antibiotics, yet only chloramphenicol and certain sulfonamide antibiotics have been consistently implicated as causes of aplastic anemia. Some pharmacological effects, such as sedation from an antihistamine, may be considered adverse effects when they are... 

Clinical practice guidelines to guide the appropriate use of erythropoietic agents have been developed (Fig. 124-14). The first step is to evaluate the underlying cause of the anemia and initiate specific therapy as indicated. For example, patients with iron deficiency anemia should receive iron supplementation. Patients with chronic bleeding or hemolysis should not receive erythropoietic therapy, as... 

The pathway is negatively regulated by protein tyrosine phosphatases and by feedback inhibition through STAT-mediated expression of suppressors of cytokine signaling (SOCs). Agonists for cytokine receptors are currently used to stimulate red blood cell maturation in anemia (erythropoietin) and to stimulate the immune system (interferons). The cascade nature of the cytokine pathway lends itself to future agents that specifically target components of the pathway. 

Hematopoiesis also requires an adequate supply of minerals e.g., iron, cobalt, and copper) and vitamins ie.g., folic acid, vitamin pyiidoxine, ascorbic acid, and riboflavin), and deficiencies generally result in characteristic anemias, or, less frequently, a general failure of hematopoiesis. Therapeutic correction of a specific deficiency state depends on the accurate diagnosis of the anemic state and knowledge about the correct dose, the use of these agents in various combinations, and the expected response. 

Weston RD (1968) Penicilloylated protein contaminating 6-amino-penicillanic acid and benzylpenicillin. Antimicrob Agents Chemother 25 553 Wheeler AW (1971) A method for measuring different classes of human immunoglobulins specific for the penicilloyl group. Immunology 21 547 White JM, Brown DL, Hepner GW (1968) Penicillin-induced haemolytic anemia. Br Med J 3 26... 

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