Androgen-insensitive testicular feminization

Complete androgen insensitivity (testicular feminization) Incomplete androgen sensitivity Androgen receptor defects 5a-Reductase deficiency... [Pg.2102]

Androgens act via the AR and play an important role in the development and differentiation of the male sexual organ. Furthermore, they are involved in several diseases, the most important being partial and complete androgen insensitivity syndrome (AIS formerly known as the testicular feminization syndrome), spinal and bulbar muscle atrophy (SBMA Kennedy s disease), and the neoplastic transformation of the prostate. The two natural occurring androgens are testosterone (T) and the... [Pg.1127]

In the X-linked recessive mutations in man and several other species often designated as the testicular feminization or androgen-insensitivity syndrome, complete or partial resistance to endogenous androgens, and to exogenous testosterone or dihydrotesterone, is man-... [Pg.218]

Androgen insensitivity syndrome (AIS) is also called testicular feminization and results from a complete or partial absence of cytoplasmic receptors for testosterone in target tissues (Holterhus et al. 2005). It is an X-linked (handXqll-ql2) disorder with an inci-... [Pg.155]

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