Endogenous Androgens

Many athletes who have used high aromatizing AAS have reported a delayed period of HPTA regeneration. As such post-cycle lean mass tissue retention suffers as a negative reaction to suppressed endogenous androgen production. If the boy s are shrunken so is the athlete they are attached to. 

We now see that the key to a growth promoting elevation of endogenous androgens is dependent upon supercharging the HPTA and HPAA. This can be accomplished by inducing one or all of the following metabolic alterations ... 

Testosterone gel is a clear, colorless hydroalcoholic gel containing 1% testosterone. It provides continuous trans-dermal delivery of testosterone, the primary circulating endogenous androgen, for 24 hours following a single application to intact, clean, dry skin of the shoulders, upper arms, or abdomen. A daily application of 5, 7.5, or 10 g contains 50, 75, or 100 mg of testosterone, respectively, to be applied daily to the skin surface. Approximately 10% of the applied testosterone dose is absorbed... 

The overall physiological effects of endogenous androgens are contributed by testosterone and its... 

In the X-linked recessive mutations in man and several other species often designated as the testicular feminization or androgen-insensitivity syndrome, complete or partial resistance to endogenous androgens, and to exogenous testosterone or dihydrotesterone, is man-... 

It is always difficult to obtain objective data on impotence as a drug-induced condition, particularly since suggestion may play an important role. There does not appear to be evidence that hyperlipoproteinaemia of itself leads to impotence. The above authors speculate that clofibrate might alter the breakdown of endogenous androgens or compete with them for albumen binding sites. 

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