Anchor principle

The initial application of the anchor principle described by Page related to data on the selectivity of amino acid-tRNA synthetases, from which he estimated intrinsic... 

A much wider generalization of the side-chain anchoring principle was reported by Jensen et al. [31]. The growing peptide is linked to the resin through a backbone amide nitrogen using an appropriate handle called a backbone amide linker (BAL) (Scheme 2C). This approach is compatible... 

W Kosch, J Maerz, KVD Bruch, H Kunz. Solid phase synthesis of glyco-peptide antigens on HYCRAM resin utilizing the allylic anchor principle. Proceedings of Innovation and Perspectives in Solid Phase Synthesis. Third International Symposium, Oxford, 1993, pp 267-272. 

Thus, in comparing the binding of 1,6-dihydropurine ribonucleoside 3 (Fig. 20.2) and its 6-hydroxy derivative 4 to adenosine deaminase, they observed AT, values for these The initial application of the anchor principle described two inhibitors of 5.4 X 10 and3X 10 M respectively,... 

Application of the anchor principle to data on the selectivity of amino acid-tRNA synthetases gives estimated intrinsic binding energies for the carboxyl and amino groups of 18 and >28kJmol, respectively. However, since the sidechains, rather than the ionic groups, are the primary determinants of amino acid/tRNA synthetase specificity, these energies are likely to be underestimates. 

Anchor principle Site-directed mutagenesis Average energy... 

The depicted target efficiently was constructed with the help of the allylic anchoring principle and a newly developed coupling reagent. 

Pullman and Pullman (1963), in their seminal book on quantum biochemistry, noted the central role occupied in life processes by molecules possessing partly or completely conjugated systems. These molecules include the coenzymes, whose precursors are the water-soluble vitamins. Stabilization of transition states by electronic delocalization, transmission of electronic perturbations over several atoms, and facilitation of electron mobility were suggested as explaining, at least in part, the reaction capabilities of coenzymes. An additional role for coenzymes (Jencks, 1975) is the provision for optimal binding interactions with specific subsites on the enzyme, the so-called "anchor principle" discussed above. In this section, we shall consider the mechanism of action of the major coenzymes. A general description of coenzyme reaction mechanisms is available (Lowe and Ingraham, 1974). 

---