Coenzyme B12 reactions

Chandra and Brown66 investigated the synthesis of x-ribonucleosides as mimetics of the lower axial ligand in coenzyme B12. Reaction of unprotected indolines with... 

A review of the biochemistry of coenzyme B12 reactions, including the methylmalonyl-CoA mutase reaction. 

The reaction of RTPR is fundamentally different from other coenzyme B 12-dependent reactions, in that it is a redox process proceeding with net reduction of the substrate, whereas the others are isomerases or isomerase/lyases. Moreover, the reduction of C2 (0H) to C2 (H) proceeds with incorporation of solvent hydrogen, unlike the other coenzyme B12 reactions. RTPR shares in common with other coenzyme Bi2-dependent reactions the role of adenosylcobalamin, which initiates the radical mechanism. It might also share with DDH the mechanism by which C2 (OH) is eliminated. 

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