Analytical Profiles of Drug Substances

G. A. Biewei, in K. Floiey, eA, Analytical Profiles of Drug Substances, Vol. 8, Academic Press, New York, p. 179. 

H. G. Brittain, Ed., Analytical Profiles of Drug Substances and Excipients, Vol. 27, Academic Press, Inc., San Diego, 2000. 

Two sensibly priced commercial databases for solubility exist [366,507], An article in the journal Analytical Profiles of Drug Substances carries solubility data [496]. Abraham and Le [508] published a list of intrinsic aqueous solubilities of 665 compounds, with many ionizable molecules. It is difficult to tell from published lists what the quality of the data for ionizable molecules is. Sometimes, it is not clear what the listed number stands for. For example, Sw, water solubility, can mean several different things either intrinsic value, or value determined at a particular pH (using buffers), or value measured by saturating distilled water with excess compound. In the most critical applications using ionizable molecules, it may be necessary to scour the original publications in order to be confident of the quality of reported values. 

W.D.Schonleber, A.L.Jacobs, and G.A.Brewer,jr. "Dihydro-ergotoxine mesilate" in Analytical Profiles of Drug Substances 1, 81... 

ANALYTICAL PROFILES OF DRUG SUBSTANCES AND EXCIPIENTS—VOLUME 26 1075-6280/00 3000... 

K. Florey, Hydrocortisone , in Analytical Profiles of Drug Substances, volume 12, K. Florey, ed.. Academic Press, Orlando, 1983, p. 111. 

Padmanabhan G, Becue I, Smith JB. Cloquinol. In Florey K, ed. Analytical Profiles of Drug Substances. Vol. 18. New York Academic Press, 1989 76-77. 

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